ITGA2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ITGA2 GPIa,CD49b integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) NM_002203 pdf

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Description

Homo sapiens integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2). This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome45 74 59 44 89 50 48 86 68
Read_Max
batR. aegyptiacusTranscriptome 169 134 153 125 93 205 100 132 233
Read_Max
bat_genomeR. aegyptiacusGenome 186 129 131 127 80 123 91 151 264
DESeq
humanH. sapiensGenome 1320.22 1794.96 2012.46 1359.55 1925.25 1140.59 1275.58 1929.03 2574.75
DESeq
batR. aegyptiacusTranscriptome 1820.74 1468.73 2536.91 1811.28 1714.82 2453.16 1598.42 1768.26 2507.92
DESeq
bat_genomeR. aegyptiacusGenome 2050.5 2031.64 2696.83 1823.88 1956.58 2916.29 1922.95 1913.38 2841.7

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1320.22 1359.55 1275.58 0.04 -0.05 -0.09
7h 1794.96 1925.25 1929.03 0.1 0.1 0.0
23h 2012.46 1140.59 2574.75 -0.82 0.36 1.17

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1320.22 1794.96 2012.46 0.44 0.61 0.17
Ebov 1359.55 1925.25 1140.59 0.5 -0.25 -0.76
Marv 1275.58 1929.03 2574.75 0.6 1.01 0.42

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1820.74 1811.28 1598.42 -0.01 -0.19 -0.18
7h 1468.73 1714.82 1768.26 0.22 0.27 0.04
23h 2536.91 2453.16 2507.92 -0.05 -0.02 0.03

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1820.74 1468.73 2536.91 -0.31 0.48 0.79
Ebov 1811.28 1714.82 2453.16 -0.08 0.44 0.52
Marv 1598.42 1768.26 2507.92 0.15 0.65 0.5