CDK2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CDK2 CDKN2, p33(CDK2) cyclin-dependent kinase 2 pdf

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Description

This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). The gene is slightly downregulated in human EBOV and MARV 23h. The bat homolog is stably expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome213 214 266 221 280 197 269 297 192
Read_Max
batR. aegyptiacusTranscriptome 213 182 123 150 165 145 153 212 179
Read_Max
bat_genomeR. aegyptiacusGenome 308 204 129 236 182 105 154 337 253
DESeq
humanH. sapiensGenome 1802.25 1800.06 1803.97 1961.83 1734.21 1397.19 1858.04 1799.54 1542.86
DESeq
batR. aegyptiacusTranscriptome 1148.63 1176.46 764.46 948.72 917.59 878.7 1048.89 996.58 861.71
DESeq
bat_genomeR. aegyptiacusGenome 1825.34 1533.31 1142.56 1917.69 1484.46 1326.3 1575.47 1539.9 1321.96

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1802.25 1961.83 1858.04 0.12 0.04 -0.08
7h 1800.06 1734.21 1799.54 -0.05 -0.0 0.05
23h 1803.97 1397.19 1542.86 -0.37 -0.23 0.14

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1802.25 1800.06 1803.97 -0.0 0.0 0.0
Ebov 1961.83 1734.21 1397.19 -0.18 -0.49 -0.31
Marv 1858.04 1799.54 1542.86 -0.05 -0.27 -0.22

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1148.63 948.72 1048.89 -0.28 -0.13 0.14
7h 1176.46 917.59 996.58 -0.36 -0.24 0.12
23h 764.46 878.7 861.71 0.2 0.17 -0.03

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1148.63 1176.46 764.46 0.03 -0.59 -0.62
Ebov 948.72 917.59 878.7 -0.05 -0.11 -0.06
Marv 1048.89 996.58 861.71 -0.07 -0.28 -0.21