PIK3CB

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PIK3CB	P110BETA, PI3K, PI3KBETA, PIK3C1	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants.

This gene is expressed in human cells and bat cells with only slight variations. We observed only one isoform, with the two additional exons in 3' that are not part of all the RefSeq-Annotations. In the intronic region between these two exons a huge number of reads (> 3000 reads) is mapped, possibly from the eukaryotic translation elongation factor 1 alpha 1.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	115	157	136	130	203	172	166	195	165
Read_Max	R. aegyptiacus	Transcriptome	102	92	55	80	72	78	72	87	77
Read_Max	R. aegyptiacus	Genome	112	83	42	75	56	47	58	100	83
DESeq	H. sapiens	Genome	1841.82	2352.83	2185.21	2065.64	2375.63	2527.57	1995.76	2185.62	2758.51
DESeq	R. aegyptiacus	Transcriptome	1540.98	1257.24	908.6	1194.12	1259.26	1266.22	1434.89	1270.88	1125.88
DESeq	R. aegyptiacus	Genome	1827.06	1434.74	1169.34	1574.05	1521.29	1576.94	1770.01	1515.32	1329.67

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1841.82	2065.64	1995.76	0.17	0.12	-0.05
7h	2352.83	2375.63	2185.62	0.01	-0.11	-0.12
23h	2185.21	2527.57	2758.51	0.21	0.34	0.13

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1841.82	2352.83	2185.21	0.35	0.25	-0.11
Ebov	2065.64	2375.63	2527.57	0.2	0.29	0.09
Marv	1995.76	2185.62	2758.51	0.13	0.47	0.34

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1540.98	1194.12	1434.89	-0.37	-0.1	0.26
7h	1257.24	1259.26	1270.88	0.0	0.02	0.01
23h	908.6	1266.22	1125.88	0.48	0.31	-0.17

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1540.98	1257.24	908.6	-0.29	-0.76	-0.47
Ebov	1194.12	1259.26	1266.22	0.08	0.08	0.01
Marv	1434.89	1270.88	1125.88	-0.18	-0.35	-0.17

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material