PIK3CB

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PIK3CB P110BETA, PI3K, PI3KBETA, PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta pdf

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Description

This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants.

This gene is expressed in human cells and bat cells with only slight variations. We observed only one isoform, with the two additional exons in 3' that are not part of all the RefSeq-Annotations. In the intronic region between these two exons a huge number of reads (> 3000 reads) is mapped, possibly from the eukaryotic translation elongation factor 1 alpha 1.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome115 157 136 130 203 172 166 195 165
Read_Max
batR. aegyptiacusTranscriptome 102 92 55 80 72 78 72 87 77
Read_Max
bat_genomeR. aegyptiacusGenome 112 83 42 75 56 47 58 100 83
DESeq
humanH. sapiensGenome 1841.82 2352.83 2185.21 2065.64 2375.63 2527.57 1995.76 2185.62 2758.51
DESeq
batR. aegyptiacusTranscriptome 1540.98 1257.24 908.6 1194.12 1259.26 1266.22 1434.89 1270.88 1125.88
DESeq
bat_genomeR. aegyptiacusGenome 1827.06 1434.74 1169.34 1574.05 1521.29 1576.94 1770.01 1515.32 1329.67

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1841.82 2065.64 1995.76 0.17 0.12 -0.05
7h 2352.83 2375.63 2185.62 0.01 -0.11 -0.12
23h 2185.21 2527.57 2758.51 0.21 0.34 0.13

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1841.82 2352.83 2185.21 0.35 0.25 -0.11
Ebov 2065.64 2375.63 2527.57 0.2 0.29 0.09
Marv 1995.76 2185.62 2758.51 0.13 0.47 0.34

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1540.98 1194.12 1434.89 -0.37 -0.1 0.26
7h 1257.24 1259.26 1270.88 0.0 0.02 0.01
23h 908.6 1266.22 1125.88 0.48 0.31 -0.17

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1540.98 1257.24 908.6 -0.29 -0.76 -0.47
Ebov 1194.12 1259.26 1266.22 0.08 0.08 0.01
Marv 1434.89 1270.88 1125.88 -0.18 -0.35 -0.17