PIK3CD

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PIK3CD	APDS, IMD14, P110DELTA, PI3K, p110D,p110D	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	NM_005026	pdf		NONE	NONE	NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.No expression in human. Bat homolog is uniformly expressed, however, the assignment is spourious with a high probability.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	21	13	18	15	18	19	15	17	17
Read_Max	R. aegyptiacus	Transcriptome	169	151	146	170	146	205	136	208	272
Read_Max	R. aegyptiacus	Genome	229	224	138	150	166	131	122	256	293
DESeq	H. sapiens	Genome	114.66	118.29	118.15	145.87	135.95	173.39	173.81	220.02	263.05
DESeq	R. aegyptiacus	Transcriptome	1831.67	1763.73	1933.47	1896.43	2018.16	2099.0	1750.81	1982.25	2440.56
DESeq	R. aegyptiacus	Genome	3873.27	4133.55	4122.8	3964.75	4369.66	4592.43	3742.44	4031.34	4947.08

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	114.66	145.87	173.81	0.35	0.6	0.25
7h	118.29	135.95	220.02	0.2	0.9	0.69
23h	118.15	173.39	263.05	0.55	1.15	0.6

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	114.66	118.29	118.15	0.04	0.04	-0.0
Ebov	145.87	135.95	173.39	-0.1	0.25	0.35
Marv	173.81	220.02	263.05	0.34	0.6	0.26

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1831.67	1896.43	1750.81	0.05	-0.07	-0.12
7h	1763.73	2018.16	1982.25	0.19	0.17	-0.03
23h	1933.47	2099.0	2440.56	0.12	0.34	0.22

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1831.67	1763.73	1933.47	-0.05	0.08	0.13
Ebov	1896.43	2018.16	2099.0	0.09	0.15	0.06
Marv	1750.81	1982.25	2440.56	0.18	0.48	0.3

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material