PIK3CD

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PIK3CD APDS, IMD14, P110DELTA, PI3K, p110D,p110D phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta NM_005026 pdf NONE NONE NONE

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Description

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.No expression in human. Bat homolog is uniformly expressed, however, the assignment is spourious with a high probability.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome21 13 18 15 18 19 15 17 17
Read_Max
batR. aegyptiacusTranscriptome 169 151 146 170 146 205 136 208 272
Read_Max
bat_genomeR. aegyptiacusGenome 229 224 138 150 166 131 122 256 293
DESeq
humanH. sapiensGenome 114.66 118.29 118.15 145.87 135.95 173.39 173.81 220.02 263.05
DESeq
batR. aegyptiacusTranscriptome 1831.67 1763.73 1933.47 1896.43 2018.16 2099.0 1750.81 1982.25 2440.56
DESeq
bat_genomeR. aegyptiacusGenome 3873.27 4133.55 4122.8 3964.75 4369.66 4592.43 3742.44 4031.34 4947.08

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 114.66 145.87 173.81 0.35 0.6 0.25
7h 118.29 135.95 220.02 0.2 0.9 0.69
23h 118.15 173.39 263.05 0.55 1.15 0.6

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 114.66 118.29 118.15 0.04 0.04 -0.0
Ebov 145.87 135.95 173.39 -0.1 0.25 0.35
Marv 173.81 220.02 263.05 0.34 0.6 0.26

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1831.67 1896.43 1750.81 0.05 -0.07 -0.12
7h 1763.73 2018.16 1982.25 0.19 0.17 -0.03
23h 1933.47 2099.0 2440.56 0.12 0.34 0.22

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1831.67 1763.73 1933.47 -0.05 0.08 0.13
Ebov 1896.43 2018.16 2099.0 0.09 0.15 0.06
Marv 1750.81 1982.25 2440.56 0.18 0.48 0.3