CDKN1B

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CDKN1B	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1,KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	NM_004064	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

CDKN1B is slightly down- for MOCK after 23h and downmodulated over all timepoints during marburg infection, while the expresion level for ebola samples dosn't change. In the RAE the regulation behaviour changes drastically: While MOCK and Ebola samples show downregulation to half of the amount of starting transcripts, the marburg expression is a little bit increased.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	328	314	264	335	328	383	362	321	229
Read_Max	R. aegyptiacus	Transcriptome	220	198	132	167	123	142	174	192	193
Read_Max	R. aegyptiacus	Genome	251	173	113	193	108	84	152	240	224
DESeq	H. sapiens	Genome	2780.5	2668.99	2343.07	2874.38	2495.95	2839.44	2632.61	2223.19	2509.51
DESeq	R. aegyptiacus	Transcriptome	705.88	709.91	609.33	633.73	577.02	663.12	717.39	623.13	716.51
DESeq	R. aegyptiacus	Genome	1439.48	1277.76	1063.34	1451.6	1154.08	1454.23	1437.15	1138.67	1352.78

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2780.5	2874.38	2632.61	0.05	-0.08	-0.13
7h	2668.99	2495.95	2223.19	-0.1	-0.26	-0.17
23h	2343.07	2839.44	2509.51	0.28	0.1	-0.18

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2780.5	2668.99	2343.07	-0.06	-0.25	-0.19
Ebov	2874.38	2495.95	2839.44	-0.2	-0.02	0.19
Marv	2632.61	2223.19	2509.51	-0.24	-0.07	0.17

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	705.88	633.73	717.39	-0.16	0.02	0.18
7h	709.91	577.02	623.13	-0.3	-0.19	0.11
23h	609.33	663.12	716.51	0.12	0.23	0.11

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	705.88	709.91	609.33	0.01	-0.21	-0.22
Ebov	633.73	577.02	663.12	-0.14	0.07	0.2
Marv	717.39	623.13	716.51	-0.2	-0.0	0.2

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material