CDKN1B

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CDKN1B CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1,KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) NM_004064 pdf

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Description

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

CDKN1B is slightly down- for MOCK after 23h and downmodulated over all timepoints during marburg infection, while the expresion level for ebola samples dosn't change. In the RAE the regulation behaviour changes drastically: While MOCK and Ebola samples show downregulation to half of the amount of starting transcripts, the marburg expression is a little bit increased.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome328 314 264 335 328 383 362 321 229
Read_Max
batR. aegyptiacusTranscriptome 220 198 132 167 123 142 174 192 193
Read_Max
bat_genomeR. aegyptiacusGenome 251 173 113 193 108 84 152 240 224
DESeq
humanH. sapiensGenome 2780.5 2668.99 2343.07 2874.38 2495.95 2839.44 2632.61 2223.19 2509.51
DESeq
batR. aegyptiacusTranscriptome 705.88 709.91 609.33 633.73 577.02 663.12 717.39 623.13 716.51
DESeq
bat_genomeR. aegyptiacusGenome 1439.48 1277.76 1063.34 1451.6 1154.08 1454.23 1437.15 1138.67 1352.78

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2780.5 2874.38 2632.61 0.05 -0.08 -0.13
7h 2668.99 2495.95 2223.19 -0.1 -0.26 -0.17
23h 2343.07 2839.44 2509.51 0.28 0.1 -0.18

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2780.5 2668.99 2343.07 -0.06 -0.25 -0.19
Ebov 2874.38 2495.95 2839.44 -0.2 -0.02 0.19
Marv 2632.61 2223.19 2509.51 -0.24 -0.07 0.17

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 705.88 633.73 717.39 -0.16 0.02 0.18
7h 709.91 577.02 623.13 -0.3 -0.19 0.11
23h 609.33 663.12 716.51 0.12 0.23 0.11

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 705.88 709.91 609.33 0.01 -0.21 -0.22
Ebov 633.73 577.02 663.12 -0.14 0.07 0.2
Marv 717.39 623.13 716.51 -0.2 -0.0 0.2