PIK3CG

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PIK3CG	PIK3CG, PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma		pdf		NONE	NONE	NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. No expression in human, but intronic uniform expression from AluYb9 repeat. The bat expression is very low but uniformly shaped.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	5	6	2	2	6	3	6	5	7
Read_Max	R. aegyptiacus	Transcriptome	10	11	7	10	10	9	9	7	9
Read_Max	R. aegyptiacus	Genome	12	11	6	6	5	5	4	9	9
DESeq	H. sapiens	Genome	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
DESeq	R. aegyptiacus	Transcriptome	41.33	56.37	62.08	85.24	61.23	84.41	68.86	51.4	83.22
DESeq	R. aegyptiacus	Genome	56.72	95.83	73.64	65.17	73.66	105.74	85.46	65.81	105.31

Human Condition Comparisons

	Mock	EBOV	MARV
3h	1.0	1.0	1.0
7h	1.0	1.0	1.0
23h	1.0	1.0	1.0

Human Time Point Comparisons

	3h	7h	23h
Mock	1.0	1.0	1.0
Ebov	1.0	1.0	1.0
Marv	1.0	1.0	1.0

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	41.33	85.24	68.86	1.04	0.74	-0.31
7h	56.37	61.23	51.4	0.12	-0.13	-0.25
23h	62.08	84.41	83.22	0.44	0.42	-0.02

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	41.33	56.37	62.08	0.45	0.59	0.14
Ebov	85.24	61.23	84.41	-0.48	-0.01	0.46
Marv	68.86	51.4	83.22	-0.42	0.27	0.7

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material