PIK3CG

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PIK3CG PIK3CG, PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma pdf NONE NONE NONE

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Description

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. No expression in human, but intronic uniform expression from AluYb9 repeat. The bat expression is very low but uniformly shaped.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome5 6 2 2 6 3 6 5 7
Read_Max
batR. aegyptiacusTranscriptome 10 11 7 10 10 9 9 7 9
Read_Max
bat_genomeR. aegyptiacusGenome 12 11 6 6 5 5 4 9 9
DESeq
humanH. sapiensGenome 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
DESeq
batR. aegyptiacusTranscriptome 41.33 56.37 62.08 85.24 61.23 84.41 68.86 51.4 83.22
DESeq
bat_genomeR. aegyptiacusGenome 56.72 95.83 73.64 65.17 73.66 105.74 85.46 65.81 105.31

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 1.0 0.0 0.0 0.0
7h 1.0 1.0 1.0 0.0 0.0 0.0
23h 1.0 1.0 1.0 0.0 0.0 0.0

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 1.0 0.0 0.0 0.0
Ebov 1.0 1.0 1.0 0.0 0.0 0.0
Marv 1.0 1.0 1.0 0.0 0.0 0.0

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 41.33 85.24 68.86 1.04 0.74 -0.31
7h 56.37 61.23 51.4 0.12 -0.13 -0.25
23h 62.08 84.41 83.22 0.44 0.42 -0.02

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 41.33 56.37 62.08 0.45 0.59 0.14
Ebov 85.24 61.23 84.41 -0.48 -0.01 0.46
Marv 68.86 51.4 83.22 -0.42 0.27 0.7