TAB3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TAB3		TGF-beta activated kinase 1/MAP3K7 binding protein 3	NM_152787	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. It is downregulated in human after 23 hours in mock, ebola infection and marburg infection probe, but upregulated in 7 hours ebola infection probe. In bat it is expressed constantly at very low level.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	392	408	313	333	513	434	448	465	225
Read_Max	R. aegyptiacus	Transcriptome	22	20	33	26	24	34	23	33	25
Read_Max	R. aegyptiacus	Genome	35	30	27	39	27	25	24	39	29
DESeq	H. sapiens	Genome	9612.05	9948.84	8236.48	9875.89	10744.14	8919.0	9943.24	8899.37	6363.07
DESeq	R. aegyptiacus	Transcriptome	236.24	203.41	211.1	277.53	263.82	361.57	239.05	220.77	220.55
DESeq	R. aegyptiacus	Genome	587.82	718.28	523.3	589.53	710.98	916.4	612.87	627.22	597.62

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	9612.05	9875.89	9943.24	0.04	0.05	0.01
7h	9948.84	10744.14	8899.37	0.11	-0.16	-0.27
23h	8236.48	8919.0	6363.07	0.11	-0.37	-0.49

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	9612.05	9948.84	8236.48	0.05	-0.22	-0.27
Ebov	9875.89	10744.14	8919.0	0.12	-0.15	-0.27
Marv	9943.24	8899.37	6363.07	-0.16	-0.64	-0.48

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	236.24	277.53	239.05	0.23	0.02	-0.22
7h	203.41	263.82	220.77	0.38	0.12	-0.26
23h	211.1	361.57	220.55	0.78	0.06	-0.71

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	236.24	203.41	211.1	-0.22	-0.16	0.05
Ebov	277.53	263.82	361.57	-0.07	0.38	0.45
Marv	239.05	220.77	220.55	-0.11	-0.12	-0.0

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material