PIK3R4

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PIK3R4	VPS15, p150	phosphoinositide-3-kinase, regulatory subunit 4	NM_014602	pdf

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Description

The phosphoinositide-3-kinase, regulatory subunit 4 (EC:2.7.11.1) gene is involved in the regulation of autophagy. This gene did not present any interesting differential gene expression pattern in the samples analyzed. Only a slightly downregulation after 23 hours of Ebola infection in humans.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	95	124	123	92	145	86	122	147	107
Read_Max	R. aegyptiacus	Transcriptome	130	111	69	107	88	96	85	138	114
Read_Max	R. aegyptiacus	Genome	143	105	50	87	74	61	75	134	111
DESeq	H. sapiens	Genome	2457.8	2695.5	2908.98	2488.83	2975.59	1632.74	2341.38	2530.14	2667.17
DESeq	R. aegyptiacus	Transcriptome	1932.48	1700.2	1527.92	2115.28	2013.78	1936.04	1911.0	2069.83	1767.91
DESeq	R. aegyptiacus	Genome	2429.5	2573.77	1860.0	2321.57	2540.32	2431.98	2377.26	2512.05	2127.64

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2457.8	2488.83	2341.38	0.02	-0.07	-0.09
7h	2695.5	2975.59	2530.14	0.14	-0.09	-0.23
23h	2908.98	1632.74	2667.17	-0.83	-0.13	0.71

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2457.8	2695.5	2908.98	0.13	0.24	0.11
Ebov	2488.83	2975.59	1632.74	0.26	-0.61	-0.87
Marv	2341.38	2530.14	2667.17	0.11	0.19	0.08

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1932.48	2115.28	1911.0	0.13	-0.02	-0.15
7h	1700.2	2013.78	2069.83	0.24	0.28	0.04
23h	1527.92	1936.04	1767.91	0.34	0.21	-0.13

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1932.48	1700.2	1527.92	-0.18	-0.34	-0.15
Ebov	2115.28	2013.78	1936.04	-0.07	-0.13	-0.06
Marv	1911.0	2069.83	1767.91	0.12	-0.11	-0.23

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material