SKP1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SKP1 EMC19, MGC34403, OCP-II, OCP2, p19A, SKP1A, TCEB1L S-phase kinase-associated protein 1 NM_170679 pdf NONE

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Description

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. There is some minor downregulation in human and bat with excpetion to the margburg virus infected bat cells, which are upregulated after 7 hours of infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome490 507 340 532 587 533 658 652 401
Read_Max
batR. aegyptiacusTranscriptome 875 776 745 784 774 873 809 1011 1092
Read_Max
bat_genomeR. aegyptiacusGenome 980 827 642 848 668 498 691 1233 1190
DESeq
humanH. sapiensGenome 1413.58 1574.66 1379.04 1621.91 1587.88 1280.08 1664.18 1614.89 1496.1
DESeq
batR. aegyptiacusTranscriptome 2658.36 2774.9 3114.7 2704.05 2863.57 2907.41 3257.01 2971.22 3190.19
DESeq
bat_genomeR. aegyptiacusGenome 4294.37 4416.48 4544.56 4487.13 4579.5 4482.78 5242.57 4887.72 4732.17

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1413.58 1621.91 1664.18 0.2 0.24 0.04
7h 1574.66 1587.88 1614.89 0.01 0.04 0.02
23h 1379.04 1280.08 1496.1 -0.11 0.12 0.22

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1413.58 1574.66 1379.04 0.16 -0.04 -0.19
Ebov 1621.91 1587.88 1280.08 -0.03 -0.34 -0.31
Marv 1664.18 1614.89 1496.1 -0.04 -0.15 -0.11

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2658.36 2704.05 3257.01 0.02 0.29 0.27
7h 2774.9 2863.57 2971.22 0.05 0.1 0.05
23h 3114.7 2907.41 3190.19 -0.1 0.03 0.13

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2658.36 2774.9 3114.7 0.06 0.23 0.17
Ebov 2704.05 2863.57 2907.41 0.08 0.1 0.02
Marv 3257.01 2971.22 3190.19 -0.13 -0.03 0.1