VAV1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
VAV1	VAV	vav 1 guanine nucleotide exchange factor		pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. It is not expressed in human and shows in bat only very low expression after 23 hours of ebola virus and marburg virus infection.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	4	3	5	5	1	3	1	2	2
Read_Max	R. aegyptiacus	Transcriptome	8	2	7	7	4	9	3	6	21
Read_Max	R. aegyptiacus	Genome	9	2	6	2	4	5	4	8	25
DESeq	H. sapiens	Genome	2.01	1.0	2.99	1.0	1.0	3.63	1.0	2.6	1.0
DESeq	R. aegyptiacus	Transcriptome	25.36	11.89	32.76	18.4	24.0	52.33	16.57	26.61	130.46
DESeq	R. aegyptiacus	Genome	22.34	17.34	46.86	9.87	30.14	58.74	19.12	26.17	184.08

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2.01	1.0	1.0	-1.01	-1.01	0.0
7h	1.0	1.0	2.6	0.0	1.38	1.38
23h	2.99	3.63	1.0	0.28	-1.58	-1.86

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2.01	1.0	2.99	-1.01	0.57	1.58
Ebov	1.0	1.0	3.63	0.0	1.86	1.86
Marv	1.0	2.6	1.0	1.38	0.0	-1.38

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	25.36	18.4	16.57	-0.46	-0.61	-0.15
7h	11.89	24.0	26.61	1.01	1.16	0.15
23h	32.76	52.33	130.46	0.68	1.99	1.32

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	25.36	11.89	32.76	-1.09	0.37	1.46
Ebov	18.4	24.0	52.33	0.38	1.51	1.12
Marv	16.57	26.61	130.46	0.68	2.98	2.29

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material