PTPN11

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PTPN11 BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2 protein tyrosine phosphatase, non-receptor type 11 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. It is constantly expressed in the human mock probes but upregulated after 7 hours and again downregulated after 23 hours of ebola virus and marburg virus infection. In bat it is downregulated in the mock probes but upregulated after ebola virus and marburg virus infection.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome1227 1232 1121 1167 1673 1370 1454 1646 1111
Read_Max
batR. aegyptiacusTranscriptome 859 788 598 767 729 955 814 967 945
Read_Max
bat_genomeR. aegyptiacusGenome 981 848 488 755 610 516 673 1119 959
DESeq
humanH. sapiensGenome 21630.17 20130.23 20365.82 20646.22 22427.87 21890.05 19973.2 18862.47 21421.73
DESeq
batR. aegyptiacusTranscriptome 8434.33 8286.39 6323.67 8038.74 8273.31 8670.18 9097.14 7960.69 6856.97
DESeq
bat_genomeR. aegyptiacusGenome 18165.79 17070.86 13064.64 18506.43 18958.65 20866.98 20569.94 17322.7 15860.09

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 21630.17 20646.22 19973.2 -0.07 -0.11 -0.05
7h 20130.23 22427.87 18862.47 0.16 -0.09 -0.25
23h 20365.82 21890.05 21421.73 0.1 0.07 -0.03

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 21630.17 20130.23 20365.82 -0.1 -0.09 0.02
Ebov 20646.22 22427.87 21890.05 0.12 0.08 -0.04
Marv 19973.2 18862.47 21421.73 -0.08 0.1 0.18

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8434.33 8038.74 9097.14 -0.07 0.11 0.18
7h 8286.39 8273.31 7960.69 -0.0 -0.06 -0.06
23h 6323.67 8670.18 6856.97 0.46 0.12 -0.34

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8434.33 8286.39 6323.67 -0.03 -0.42 -0.39
Ebov 8038.74 8273.31 8670.18 0.04 0.11 0.07
Marv 9097.14 7960.69 6856.97 -0.19 -0.41 -0.22