PTPN11
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| PTPN11 | BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2 | protein tyrosine phosphatase, non-receptor type 11 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. It is constantly expressed in the human mock probes but upregulated after 7 hours and again downregulated after 23 hours of ebola virus and marburg virus infection. In bat it is downregulated in the mock probes but upregulated after ebola virus and marburg virus infection.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 1227 | 1232 | 1121 | 1167 | 1673 | 1370 | 1454 | 1646 | 1111 |
Read_Max |  | R. aegyptiacus | Transcriptome | 859 | 788 | 598 | 767 | 729 | 955 | 814 | 967 | 945 |
Read_Max |  | R. aegyptiacus | Genome | 981 | 848 | 488 | 755 | 610 | 516 | 673 | 1119 | 959 |
DESeq | | H. sapiens | Genome | 21630.17 | 20130.23 | 20365.82 | 20646.22 | 22427.87 | 21890.05 | 19973.2 | 18862.47 | 21421.73 |
DESeq | | R. aegyptiacus | Transcriptome | 8434.33 | 8286.39 | 6323.67 | 8038.74 | 8273.31 | 8670.18 | 9097.14 | 7960.69 | 6856.97 |
DESeq | | R. aegyptiacus | Genome | 18165.79 | 17070.86 | 13064.64 | 18506.43 | 18958.65 | 20866.98 | 20569.94 | 17322.7 | 15860.09 |