TIAM1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TIAM1 T-cell lymphoma invasion and metastasis 1 NM_003253 pdf NONE

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Description

TIAM1 encodes for the T-cell lymphoma invasion and metastasis 1 protein. It modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. It activates RAC1, CDC42, and to a lesser extent RHOA. In human it is not expressed. In bat it is constantly expressed and sligthly downregulated in the mock probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome6 8 6 4 8 5 6 6 4
Read_Max
batR. aegyptiacusTranscriptome 62 52 23 32 37 27 40 35 46
Read_Max
bat_genomeR. aegyptiacusGenome 66 45 16 48 30 21 34 44 54
DESeq
humanH. sapiensGenome 1.0 1.0 3.98 4.42 2.63 1.0 2.75 1.0 5.35
DESeq
batR. aegyptiacusTranscriptome 1063.78 927.75 438.31 778.4 786.18 548.92 1028.86 724.76 629.04
DESeq
bat_genomeR. aegyptiacusGenome 1435.18 1057.8 610.33 1303.48 1123.95 882.46 1501.25 1028.45 843.35

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 4.42 2.75 2.14 1.46 -0.68
7h 1.0 2.63 1.0 1.4 0.0 -1.4
23h 3.98 1.0 5.35 -1.99 0.43 2.42

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 3.98 0.0 1.99 1.99
Ebov 4.42 2.63 1.0 -0.75 -2.14 -1.4
Marv 2.75 1.0 5.35 -1.46 0.96 2.42

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1063.78 778.4 1028.86 -0.45 -0.05 0.4
7h 927.75 786.18 724.76 -0.24 -0.36 -0.12
23h 438.31 548.92 629.04 0.32 0.52 0.2

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1063.78 927.75 438.31 -0.2 -1.28 -1.08
Ebov 778.4 786.18 548.92 0.01 -0.5 -0.52
Marv 1028.86 724.76 629.04 -0.51 -0.71 -0.2