USP7

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
USP7 HAUSP ubiquitin specific peptidase 7 (herpes virus-associated) pdf

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Description

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome472 591 515 488 596 614 590 669 409
Read_Max
batR. aegyptiacusTranscriptome 508 425 324 434 326 500 335 502 510
Read_Max
bat_genomeR. aegyptiacusGenome 557 400 277 402 278 293 283 612 571
DESeq
humanH. sapiensGenome 8453.16 8124.29 7045.09 8240.15 7503.72 9120.34 7911.63 7551.66 6650.13
DESeq
batR. aegyptiacusTranscriptome 6785.97 6105.21 5209.63 5958.34 5785.27 6923.77 5713.21 6057.11 5623.63
DESeq
bat_genomeR. aegyptiacusGenome 8261.32 7409.18 6065.37 7796.18 7106.42 8438.17 7058.69 7179.33 6718.54

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8453.16 8240.15 7911.63 -0.04 -0.1 -0.06
7h 8124.29 7503.72 7551.66 -0.11 -0.11 0.01
23h 7045.09 9120.34 6650.13 0.37 -0.08 -0.46

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8453.16 8124.29 7045.09 -0.06 -0.26 -0.21
Ebov 8240.15 7503.72 9120.34 -0.14 0.15 0.28
Marv 7911.63 7551.66 6650.13 -0.07 -0.25 -0.18

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6785.97 5958.34 5713.21 -0.19 -0.25 -0.06
7h 6105.21 5785.27 6057.11 -0.08 -0.01 0.07
23h 5209.63 6923.77 5623.63 0.41 0.11 -0.3

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6785.97 6105.21 5209.63 -0.15 -0.38 -0.23
Ebov 5958.34 5785.27 6923.77 -0.04 0.22 0.26
Marv 5713.21 6057.11 5623.63 0.08 -0.02 -0.11