USP7

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
USP7	HAUSP	ubiquitin specific peptidase 7 (herpes virus-associated)		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	472	591	515	488	596	614	590	669	409
Read_Max	R. aegyptiacus	Transcriptome	508	425	324	434	326	500	335	502	510
Read_Max	R. aegyptiacus	Genome	557	400	277	402	278	293	283	612	571
DESeq	H. sapiens	Genome	8453.16	8124.29	7045.09	8240.15	7503.72	9120.34	7911.63	7551.66	6650.13
DESeq	R. aegyptiacus	Transcriptome	6785.97	6105.21	5209.63	5958.34	5785.27	6923.77	5713.21	6057.11	5623.63
DESeq	R. aegyptiacus	Genome	8261.32	7409.18	6065.37	7796.18	7106.42	8438.17	7058.69	7179.33	6718.54

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8453.16	8240.15	7911.63	-0.04	-0.1	-0.06
7h	8124.29	7503.72	7551.66	-0.11	-0.11	0.01
23h	7045.09	9120.34	6650.13	0.37	-0.08	-0.46

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8453.16	8124.29	7045.09	-0.06	-0.26	-0.21
Ebov	8240.15	7503.72	9120.34	-0.14	0.15	0.28
Marv	7911.63	7551.66	6650.13	-0.07	-0.25	-0.18

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	6785.97	5958.34	5713.21	-0.19	-0.25	-0.06
7h	6105.21	5785.27	6057.11	-0.08	-0.01	0.07
23h	5209.63	6923.77	5623.63	0.41	0.11	-0.3

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	6785.97	6105.21	5209.63	-0.15	-0.38	-0.23
Ebov	5958.34	5785.27	6923.77	-0.04	0.22	0.26
Marv	5713.21	6057.11	5623.63	0.08	-0.02	-0.11

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material