DIABLO

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DIABLO	SMAC, DFNA64,SMAC, DIABLO-S, FLJ25049, FLJ10537, DFNA64	diablo, IAP-binding mitochondrial protein	NM_019887	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.

This gene was found with no sigificantly different expression in human probes, no homolog was found in bat probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	116	153	112	106	139	190	115	179	99
Read_Max	R. aegyptiacus	Transcriptome	342	319	200	323	257	303	276	320	340
Read_Max	R. aegyptiacus	Genome	379	334	210	327	221	173	237	395	401
DESeq	H. sapiens	Genome	899.09	937.24	750.58	893.01	899.31	1224.81	848.38	971.41	875.23
DESeq	R. aegyptiacus	Transcriptome	1289.78	1345.29	1148.02	1264.62	1275.68	1248.25	1422.65	1134.56	1252.71
DESeq	R. aegyptiacus	Genome	1894.96	1821.72	1665.86	2054.95	1957.7	2011.64	2211.95	1773.03	1893.9

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	899.09	893.01	848.38	-0.01	-0.08	-0.07
7h	937.24	899.31	971.41	-0.06	0.05	0.11
23h	750.58	1224.81	875.23	0.71	0.22	-0.48

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	899.09	937.24	750.58	0.06	-0.26	-0.32
Ebov	893.01	899.31	1224.81	0.01	0.46	0.45
Marv	848.38	971.41	875.23	0.2	0.04	-0.15

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1289.78	1264.62	1422.65	-0.03	0.14	0.17
7h	1345.29	1275.68	1134.56	-0.08	-0.25	-0.17
23h	1148.02	1248.25	1252.71	0.12	0.13	0.01

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1289.78	1345.29	1148.02	0.06	-0.17	-0.23
Ebov	1264.62	1275.68	1248.25	0.01	-0.02	-0.03
Marv	1422.65	1134.56	1252.71	-0.33	-0.18	0.14

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material