DIABLO

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DIABLO SMAC, DFNA64,SMAC, DIABLO-S, FLJ25049, FLJ10537, DFNA64 diablo, IAP-binding mitochondrial protein NM_019887 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.

This gene was found with no sigificantly different expression in human probes, no homolog was found in bat probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome116 153 112 106 139 190 115 179 99
Read_Max
batR. aegyptiacusTranscriptome 342 319 200 323 257 303 276 320 340
Read_Max
bat_genomeR. aegyptiacusGenome 379 334 210 327 221 173 237 395 401
DESeq
humanH. sapiensGenome 899.09 937.24 750.58 893.01 899.31 1224.81 848.38 971.41 875.23
DESeq
batR. aegyptiacusTranscriptome 1289.78 1345.29 1148.02 1264.62 1275.68 1248.25 1422.65 1134.56 1252.71
DESeq
bat_genomeR. aegyptiacusGenome 1894.96 1821.72 1665.86 2054.95 1957.7 2011.64 2211.95 1773.03 1893.9

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 899.09 893.01 848.38 -0.01 -0.08 -0.07
7h 937.24 899.31 971.41 -0.06 0.05 0.11
23h 750.58 1224.81 875.23 0.71 0.22 -0.48

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 899.09 937.24 750.58 0.06 -0.26 -0.32
Ebov 893.01 899.31 1224.81 0.01 0.46 0.45
Marv 848.38 971.41 875.23 0.2 0.04 -0.15

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1289.78 1264.62 1422.65 -0.03 0.14 0.17
7h 1345.29 1275.68 1134.56 -0.08 -0.25 -0.17
23h 1148.02 1248.25 1252.71 0.12 0.13 0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1289.78 1345.29 1148.02 0.06 -0.17 -0.23
Ebov 1264.62 1275.68 1248.25 0.01 -0.02 -0.03
Marv 1422.65 1134.56 1252.71 -0.33 -0.18 0.14