DUSP2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DUSP2	PAC-1	dual specificity phosphatase 2	NM_004418	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens dual specificity phosphatase 2 (DUSP2) protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.

No expression could be observed and no homolog was found in RAE.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	2	2	0	0	3	0	1	5	4
Read_Max	R. aegyptiacus	Transcriptome	1	NA	2	2	1	2	NA	4	4
Read_Max	R. aegyptiacus	Genome	2	2	2	1	1	2	0	5	5
DESeq	H. sapiens	Genome	6.07	5.08	1.0	1.0	8.32	1.0	4.51	8.99	8.61
DESeq	R. aegyptiacus	Transcriptome	2.68	1.0	8.33	4.66	3.19	3.57	1.0	12.57	9.75
DESeq	R. aegyptiacus	Genome	3.44	2.74	11.16	1.97	1.12	2.61	0.0	11.1	11.13

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	6.07	1.0	4.51	-2.6	-0.43	2.17
7h	5.08	8.32	8.99	0.71	0.82	0.11
23h	1.0	1.0	8.61	0.0	3.11	3.11

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	6.07	5.08	1.0	-0.26	-2.6	-2.34
Ebov	1.0	8.32	1.0	3.06	0.0	-3.06
Marv	4.51	8.99	8.61	1.0	0.93	-0.06

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2.68	4.66	1.0	0.8	-1.42	-2.22
7h	1.0	3.19	12.57	1.67	3.65	1.98
23h	8.33	3.57	9.75	-1.22	0.23	1.45

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2.68	1.0	8.33	-1.42	1.64	3.06
Ebov	4.66	3.19	3.57	-0.55	-0.38	0.16
Marv	1.0	12.57	9.75	3.65	3.29	-0.37

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material