SOCS1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SOCS1 NM_003745, NP_003736, O15097, O15524, Q9NSA7, SOCS1_HUMAN, SSI1, TIP3,SOCS-1, SSI-1, JAB, Cish1 suppressor of cytokine signaling 1 pdf

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Description

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

No significant differences concerning the expression levels were observed. In general expression was rather low.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome13 11 11 9 25 5 12 14 2
Read_Max
batR. aegyptiacusTranscriptome NA 1 2 2 2 1 NA 3 2
Read_Max
bat_genomeR. aegyptiacusGenome 2 2 2 1 2 2 0 8 2
DESeq
humanH. sapiensGenome 52.75 51.99 46.67 42.06 61.97 11.53 44.86 60.15 8.61
DESeq
batR. aegyptiacusTranscriptome 1.0 1.91 3.44 3.75 3.19 3.57 1.0 3.48 2.75
DESeq
bat_genomeR. aegyptiacusGenome 1.72 3.65 11.16 2.96 4.46 13.05 0.0 11.1 3.42

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 52.75 42.06 44.86 -0.33 -0.23 0.09
7h 51.99 61.97 60.15 0.25 0.21 -0.04
23h 46.67 11.53 8.61 -2.02 -2.44 -0.42

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 52.75 51.99 46.67 -0.02 -0.18 -0.16
Ebov 42.06 61.97 11.53 0.56 -1.87 -2.43
Marv 44.86 60.15 8.61 0.42 -2.38 -2.8

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 3.75 1.0 1.91 0.0 -1.91
7h 1.91 3.19 3.48 0.74 0.87 0.13
23h 3.44 3.57 2.75 0.05 -0.32 -0.38

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.91 3.44 0.93 1.78 0.85
Ebov 3.75 3.19 3.57 -0.23 -0.07 0.16
Marv 1.0 3.48 2.75 1.8 1.46 -0.34