SOCS1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| SOCS1 | NM_003745, NP_003736, O15097, O15524, Q9NSA7, SOCS1_HUMAN, SSI1, TIP3,SOCS-1, SSI-1, JAB, Cish1 | suppressor of cytokine signaling 1 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
No significant differences concerning the expression levels were observed. In general expression was rather low.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 13 | 11 | 11 | 9 | 25 | 5 | 12 | 14 | 2 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | 1 | 2 | 2 | 2 | 1 | NA | 3 | 2 |
Read_Max |  | R. aegyptiacus | Genome | 2 | 2 | 2 | 1 | 2 | 2 | 0 | 8 | 2 |
DESeq | | H. sapiens | Genome | 52.75 | 51.99 | 46.67 | 42.06 | 61.97 | 11.53 | 44.86 | 60.15 | 8.61 |
DESeq | | R. aegyptiacus | Transcriptome | 1.0 | 1.91 | 3.44 | 3.75 | 3.19 | 3.57 | 1.0 | 3.48 | 2.75 |
DESeq | | R. aegyptiacus | Genome | 1.72 | 3.65 | 11.16 | 2.96 | 4.46 | 13.05 | 0.0 | 11.1 | 3.42 |