SOCS3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SOCS3 CIS3, NM_003955, NP_003946, O14509, O14543, SOCS3_HUMAN, SSI3,SSI-3, CIS3, SOCS-3, Cish3 suppressor of cytokine signaling 3 pdf

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Description

essor of cytokine signaling 3 (SOCS3), mRNA. RefSeq Summary (NM\_003955): This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

This gene seems to be not expressed as there were only very mappings to this locus.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome5 6 8 4 4 11 8 4 5
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 24 25 30 23 25 23 17 43 61
DESeq
humanH. sapiensGenome 24.34 29.56 40.71 21.53 17.26 53.64 25.56 20.98 45.58
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 225.16 308.49 368.21 230.08 391.76 513.03 240.65 265.64 437.51

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 24.34 21.53 25.56 -0.18 0.07 0.25
7h 29.56 17.26 20.98 -0.78 -0.49 0.28
23h 40.71 53.64 45.58 0.4 0.16 -0.23

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 24.34 29.56 40.71 0.28 0.74 0.46
Ebov 21.53 17.26 53.64 -0.32 1.32 1.64
Marv 25.56 20.98 45.58 -0.28 0.83 1.12

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA