SOCS5

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
SOCS5	CIS6, CISH5, CISH6, KIAA0671, NM_014011, NP_659198, O75159, Q53SD4, Q8IYZ4, SOCS5_HUMAN,KIAA0671, SOCS-5, CIS6, Cish5	suppressor of cytokine signaling 5		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.

There were no strong changes concerning the expression and pattern within this gene.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	68	70	84	63	76	130	82	100	74
Read_Max	R. aegyptiacus	Transcriptome	318	251	277	243	227	261	199	317	365
Read_Max	R. aegyptiacus	Genome	378	276	246	258	217	157	191	411	346
DESeq	H. sapiens	Genome	996.51	963.76	1098.07	851.95	970.85	1316.92	1008.03	985.8	1240.58
DESeq	R. aegyptiacus	Transcriptome	1876.19	1616.69	2095.94	1666.6	1664.44	1610.11	1987.76	1863.27	1948.98
DESeq	R. aegyptiacus	Genome	3357.64	3021.9	3617.35	3056.26	3304.87	3236.11	3697.46	3543.68	3598.57

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	996.51	851.95	1008.03	-0.23	0.02	0.24
7h	963.76	970.85	985.8	0.01	0.03	0.02
23h	1098.07	1316.92	1240.58	0.26	0.18	-0.09

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	996.51	963.76	1098.07	-0.05	0.14	0.19
Ebov	851.95	970.85	1316.92	0.19	0.63	0.44
Marv	1008.03	985.8	1240.58	-0.03	0.3	0.33

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1876.19	1666.6	1987.76	-0.17	0.08	0.25
7h	1616.69	1664.44	1863.27	0.04	0.2	0.16
23h	2095.94	1610.11	1948.98	-0.38	-0.1	0.28

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1876.19	1616.69	2095.94	-0.21	0.16	0.37
Ebov	1666.6	1664.44	1610.11	-0.0	-0.05	-0.05
Marv	1987.76	1863.27	1948.98	-0.09	-0.03	0.06

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material