SOCS6
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| SOCS6 | CIS4, NM_004232, NP_004223, O14544, Q8WUM3, SOCS4, SOCS6_HUMAN, SSI4, HSPC060, STATI4, STAI4, Cish4 | suppressor of cytokine signaling 6 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
This gene was twofold downregulated for the MARV 23 h p.i. sample. In general the expression was rather low, with a maximum of 49 reads.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 35 | 30 | 24 | 35 | 45 | 42 | 49 | 41 | 19 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 403 | 299 | 151 | 294 | 191 | 195 | 257 | 361 | 291 |
DESeq | | H. sapiens | Genome | 698.16 | 567.03 | 490.46 | 593.01 | 543.24 | 715.55 | 704.52 | 550.15 | 469.65 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 5871.35 | 5524.48 | 3452.22 | 5331.42 | 5688.93 | 6729.39 | 7441.03 | 5204.9 | 4300.65 |