SOCS7

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
SOCS7	A2VCU2, NAP4, NM_014598, NP_055413, O14512, Q0IJ63, SOCS6, SOCS7_HUMAN,NAP4, NCKAP4	suppressor of cytokine signaling 7	XM_371052	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens suppressor of cytokine signaling 7 (SOCS7), mRNA Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

This gene is upregulated till 7h in all HG19 samples. While MOCK hold this level till 23h, ebola infected cells show further increase of transcripts and marburg decreases. The RAE homolog is slightly upregulated for marburg infected samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	75	93	92	79	97	172	85	103	69
Read_Max	R. aegyptiacus	Transcriptome	65	55	43	49	50	74	49	60	44
Read_Max	R. aegyptiacus	Genome	76	75	44	58	54	55	45	102	82
DESeq	H. sapiens	Genome	2383.72	2453.79	2715.38	2351.95	2504.89	4465.92	2233.49	2320.72	2399.69
DESeq	R. aegyptiacus	Transcriptome	419.39	410.37	405.33	402.06	358.0	432.15	376.99	388.49	322.89
DESeq	R. aegyptiacus	Genome	1664.64	1629.14	1380.22	1579.97	1421.95	1979.0	1609.21	1574.0	1374.19

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2383.72	2351.95	2233.49	-0.02	-0.09	-0.07
7h	2453.79	2504.89	2320.72	0.03	-0.08	-0.11
23h	2715.38	4465.92	2399.69	0.72	-0.18	-0.9

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2383.72	2453.79	2715.38	0.04	0.19	0.15
Ebov	2351.95	2504.89	4465.92	0.09	0.93	0.83
Marv	2233.49	2320.72	2399.69	0.06	0.1	0.05

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	419.39	402.06	376.99	-0.06	-0.15	-0.09
7h	410.37	358.0	388.49	-0.2	-0.08	0.12
23h	405.33	432.15	322.89	0.09	-0.33	-0.42

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	419.39	410.37	405.33	-0.03	-0.05	-0.02
Ebov	402.06	358.0	432.15	-0.17	0.1	0.27
Marv	376.99	388.49	322.89	0.04	-0.22	-0.27

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material