CISH

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CISH CIS, G18, CIS-1, SOCS cytokine inducible SH2-containing protein NM_145071 pdf

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Description

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. The gene shows an overall low expression in all human samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome5 4 6 5 7 8 7 6 4
Read_Max
batR. aegyptiacusTranscriptome 17 19 25 23 23 29 12 22 39
Read_Max
bat_genomeR. aegyptiacusGenome 20 27 20 13 13 20 11 32 37
DESeq
humanH. sapiensGenome 23.33 19.36 22.84 24.95 24.58 28.63 32.58 21.78 20.57
DESeq
batR. aegyptiacusTranscriptome 41.33 60.0 141.48 91.65 88.61 133.17 35.48 75.36 149.7
DESeq
bat_genomeR. aegyptiacusGenome 72.19 157.89 251.05 110.6 150.68 315.91 86.59 164.14 271.41

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 23.33 24.95 32.58 0.1 0.48 0.38
7h 19.36 24.58 21.78 0.34 0.17 -0.17
23h 22.84 28.63 20.57 0.33 -0.15 -0.48

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 23.33 19.36 22.84 -0.27 -0.03 0.24
Ebov 24.95 24.58 28.63 -0.02 0.2 0.22
Marv 32.58 21.78 20.57 -0.58 -0.66 -0.08

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 41.33 91.65 35.48 1.15 -0.22 -1.37
7h 60.0 88.61 75.36 0.56 0.33 -0.23
23h 141.48 133.17 149.7 -0.09 0.08 0.17

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 41.33 60.0 141.48 0.54 1.78 1.24
Ebov 91.65 88.61 133.17 -0.05 0.54 0.59
Marv 35.48 75.36 149.7 1.09 2.08 0.99