CISH
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| CISH | CIS, G18, CIS-1, SOCS | cytokine inducible SH2-containing protein | NM_145071 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. The gene shows an overall low expression in all human samples.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 5 | 4 | 6 | 5 | 7 | 8 | 7 | 6 | 4 |
Read_Max |  | R. aegyptiacus | Transcriptome | 17 | 19 | 25 | 23 | 23 | 29 | 12 | 22 | 39 |
Read_Max |  | R. aegyptiacus | Genome | 20 | 27 | 20 | 13 | 13 | 20 | 11 | 32 | 37 |
DESeq | | H. sapiens | Genome | 23.33 | 19.36 | 22.84 | 24.95 | 24.58 | 28.63 | 32.58 | 21.78 | 20.57 |
DESeq | | R. aegyptiacus | Transcriptome | 41.33 | 60.0 | 141.48 | 91.65 | 88.61 | 133.17 | 35.48 | 75.36 | 149.7 |
DESeq | | R. aegyptiacus | Genome | 72.19 | 157.89 | 251.05 | 110.6 | 150.68 | 315.91 | 86.59 | 164.14 | 271.41 |