HAVCR1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HAVCR1 HAVCR-1, TIM-1, TIM1, HAVCR, TIMD1 hepatitis A virus cellular receptor 1 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals.

This gene is well expressed in all samples and shows an down regulation in EBOV 23h in human cells and a upregulation in MARV 23h p.i.. Interestingly the 5' region is also expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome748 414 471 385 468 349 416 437 605
Read_Max
batR. aegyptiacusTranscriptome 37 39 8 10 9 12 30 13 14
Read_Max
bat_genomeR. aegyptiacusGenome 41 32 16 38 14 8 20 29 26
DESeq
humanH. sapiensGenome 5218.02 3751.07 4903.57 3621.53 3673.1 2749.96 3388.76 3001.76 7044.83
DESeq
batR. aegyptiacusTranscriptome 133.74 158.03 48.64 53.19 59.04 52.33 140.05 66.27 41.24
DESeq
bat_genomeR. aegyptiacusGenome 427.12 319.44 227.62 425.61 267.87 297.63 385.71 311.63 277.41

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5218.02 3621.53 3388.76 -0.53 -0.62 -0.1
7h 3751.07 3673.1 3001.76 -0.03 -0.32 -0.29
23h 4903.57 2749.96 7044.83 -0.83 0.52 1.36

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5218.02 3751.07 4903.57 -0.48 -0.09 0.39
Ebov 3621.53 3673.1 2749.96 0.02 -0.4 -0.42
Marv 3388.76 3001.76 7044.83 -0.17 1.06 1.23

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 133.74 53.19 140.05 -1.33 0.07 1.4
7h 158.03 59.04 66.27 -1.42 -1.25 0.17
23h 48.64 52.33 41.24 0.11 -0.24 -0.34

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 133.74 158.03 48.64 0.24 -1.46 -1.7
Ebov 53.19 59.04 52.33 0.15 -0.02 -0.17
Marv 140.05 66.27 41.24 -1.08 -1.76 -0.68