LZTS1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
LZTS1 F37, FEZ1,FEZ1 leucine zipper, putative tumor suppressor 1 NM_021020 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex.

Expression level is rapidly decreased in Ebola infected human cells after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome24 15 10 20 14 3 17 19 7
Read_Max
batR. aegyptiacusTranscriptome 68 51 41 52 49 45 39 57 58
Read_Max
bat_genomeR. aegyptiacusGenome 73 57 39 68 50 29 40 87 84
DESeq
humanH. sapiensGenome 466.79 298.8 163.82 413.93 212.37 11.53 368.55 239.21 67.33
DESeq
batR. aegyptiacusTranscriptome 450.48 483.89 423.65 434.11 479.55 315.38 390.34 452.11 468.09
DESeq
bat_genomeR. aegyptiacusGenome 1549.48 1584.42 1704.91 1682.67 1619.51 1435.95 1458.52 1505.8 1822.83

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 466.79 413.93 368.55 -0.17 -0.34 -0.17
7h 298.8 212.37 239.21 -0.49 -0.32 0.17
23h 163.82 11.53 67.33 -3.83 -1.28 2.55

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 466.79 298.8 163.82 -0.64 -1.51 -0.87
Ebov 413.93 212.37 11.53 -0.96 -5.17 -4.2
Marv 368.55 239.21 67.33 -0.62 -2.45 -1.83

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 450.48 434.11 390.34 -0.05 -0.21 -0.15
7h 483.89 479.55 452.11 -0.01 -0.1 -0.09
23h 423.65 315.38 468.09 -0.43 0.14 0.57

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 450.48 483.89 423.65 0.1 -0.09 -0.19
Ebov 434.11 479.55 315.38 0.14 -0.46 -0.6
Marv 390.34 452.11 468.09 0.21 0.26 0.05