BHLHE41

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
BHLHE41 A2I2N8, BHE41_HUMAN, BHLHB3, DEC2, NM_030762, NP_110389, Q9C0J9, SHARP1, uc021qwg.1,DEC2, SHARP-1, bHLHe41 basic helix-loop-helix family, member e41 NM_030762 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype.

This gene is slightly expressed in Ebola and Marburg infected cells in human cells after 23 h. The other probes show no expression. In bat cells all probes are slightly expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome4 3 2 3 4 19 3 8 12
Read_Max
batR. aegyptiacusTranscriptome 35 18 28 30 24 48 19 28 37
Read_Max
bat_genomeR. aegyptiacusGenome 30 23 25 17 18 31 17 35 39
DESeq
humanH. sapiensGenome 12.16 19.36 4.97 18.11 13.19 137.86 13.28 37.77 128.22
DESeq
batR. aegyptiacusTranscriptome 124.5 113.55 190.34 113.63 124.75 265.34 133.38 117.5 175.07
DESeq
bat_genomeR. aegyptiacusGenome 210.55 209.0 353.7 201.45 247.78 613.54 211.41 231.54 282.54

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 12.16 18.11 13.28 0.57 0.13 -0.45
7h 19.36 13.19 37.77 -0.55 0.96 1.52
23h 4.97 137.86 128.22 4.79 4.69 -0.1

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 12.16 19.36 4.97 0.67 -1.29 -1.96
Ebov 18.11 13.19 137.86 -0.46 2.93 3.39
Marv 13.28 37.77 128.22 1.51 3.27 1.76

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 124.5 113.63 133.38 -0.13 0.1 0.23
7h 113.55 124.75 117.5 0.14 0.05 -0.09
23h 190.34 265.34 175.07 0.48 -0.12 -0.6

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 124.5 113.55 190.34 -0.13 0.61 0.75
Ebov 113.63 124.75 265.34 0.13 1.22 1.09
Marv 133.38 117.5 175.07 -0.18 0.39 0.58