EDN1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
EDN1 EDN1, ARCND3, ET1, HDLCQ7, PPET1, QME,ET1 endothelin 1 NM_001955 pdf

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Description

The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

Eyeballing the expression data does not confirm any remarkable change in expression pattern due to Ebola or Marburg virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome16 11 2 14 14 26 25 45 24
Read_Max
batR. aegyptiacusTranscriptome 215 211 206 164 152 281 211 239 217
Read_Max
bat_genomeR. aegyptiacusGenome 233 167 178 187 123 143 180 291 237
DESeq
humanH. sapiensGenome 71.02 61.17 7.95 119.63 61.16 152.33 125.56 221.62 215.21
DESeq
batR. aegyptiacusTranscriptome 842.82 846.06 986.78 739.03 708.43 1075.02 1055.56 854.47 852.97
DESeq
bat_genomeR. aegyptiacusGenome 2015.27 1780.65 2145.64 2100.38 1568.17 2109.54 2417.74 1968.88 1861.36

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 71.02 119.63 125.56 0.75 0.82 0.07
7h 61.17 61.16 221.62 0.0 1.86 1.86
23h 7.95 152.33 215.21 4.26 4.76 0.5

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 71.02 61.17 7.95 -0.22 -3.16 -2.94
Ebov 119.63 61.16 152.33 -0.97 0.35 1.32
Marv 125.56 221.62 215.21 0.82 0.78 -0.04

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 842.82 739.03 1055.56 -0.19 0.32 0.51
7h 846.06 708.43 854.47 -0.26 0.01 0.27
23h 986.78 1075.02 852.97 0.12 -0.21 -0.33

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 842.82 846.06 986.78 0.01 0.23 0.22
Ebov 739.03 708.43 1075.02 -0.06 0.54 0.6
Marv 1055.56 854.47 852.97 -0.3 -0.31 -0.0