EGR1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
EGR1 EGR1_HUMAN, KROX24, NM_001964, NP_001955, P18146, ZNF225,TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225 early growth response 1 NM_001964 pdf

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Description

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a cancer suppressor gene.

The early growth response protein 1 (EGR-1) is a transcription factor which is highly up-regulated in EBOV-infected cells (human: 20X, bat: 2.5X). EGR-1 may be up-regulated by a variety of stimuli including MAPKs as MAPK14, \update and MAPK1 [Hsia \emph, 2013, 3:706-723] then it functions as a convergence point for many signaling pathways leading to regulations of proliferation as well as apoptosis [Pagel and Deindl, J Biochem Biophys, 2011, 48:226-235]. Target genes are tissue factor, vascular endothelial growth factor (VEGFA) and intercellular adhesion molecule 1 (ICAM1), proteins that are common in organ injury [Ngiam et al., Am J Physiol Lung Cell Mol Physiol}, 2007, 293:L1089-1091]. Furthermore it is known that viral infections, as lytic HSV-1 infection induce EGR-1 expression in infected cells and that this seems to enhance viral replication [Bedadala et al., Virol J, 2011, 8:262; Hsia et al., Br Microbiol Res J}, 2013, 3:706-723].

The gene overlaps with LOC100652898.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome17 33 31 13 21 411 16 63 36
Read_Max
batR. aegyptiacusTranscriptome 189 203 154 147 141 349 118 196 337
Read_Max
bat_genomeR. aegyptiacusGenome 193 125 132 186 120 241 107 259 374
DESeq
humanH. sapiensGenome 129.88 287.58 308.78 137.88 179.04 4111.94 148.37 444.64 326.12
DESeq
batR. aegyptiacusTranscriptome 1230.97 1995.19 1620.76 1135.51 1228.6 2577.63 1133.43 1237.83 2050.44
DESeq
bat_genomeR. aegyptiacusGenome 1776.36 1600.85 2484.84 2966.4 2074.89 4905.73 1963.43 2029.15 3368.26

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 129.88 137.88 148.37 0.09 0.19 0.11
7h 287.58 179.04 444.64 -0.68 0.63 1.31
23h 308.78 4111.94 326.12 3.74 0.08 -3.66

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 129.88 287.58 308.78 1.15 1.25 0.1
Ebov 137.88 179.04 4111.94 0.38 4.9 4.52
Marv 148.37 444.64 326.12 1.58 1.14 -0.45

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1230.97 1135.51 1133.43 -0.12 -0.12 -0.0
7h 1995.19 1228.6 1237.83 -0.7 -0.69 0.01
23h 1620.76 2577.63 2050.44 0.67 0.34 -0.33

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1230.97 1995.19 1620.76 0.7 0.4 -0.3
Ebov 1135.51 1228.6 2577.63 0.11 1.18 1.07
Marv 1133.43 1237.83 2050.44 0.13 0.86 0.73