EGR1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| EGR1 | EGR1_HUMAN, KROX24, NM_001964, NP_001955, P18146, ZNF225,TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225 | early growth response 1 | NM_001964 |  |
 |
 |
 |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a cancer suppressor gene.
The early growth response protein 1 (EGR-1) is a transcription factor which is highly up-regulated in EBOV-infected cells (human: 20X, bat: 2.5X). EGR-1 may be up-regulated by a variety of stimuli including MAPKs as MAPK14, \update and MAPK1 [Hsia \emph, 2013, 3:706-723] then it functions as a convergence point for many signaling pathways leading to regulations of proliferation as well as apoptosis [Pagel and Deindl, J Biochem Biophys, 2011, 48:226-235]. Target genes are tissue factor, vascular endothelial growth factor (VEGFA) and intercellular adhesion molecule 1 (ICAM1), proteins that are common in organ injury [Ngiam et al., Am J Physiol Lung Cell Mol Physiol}, 2007, 293:L1089-1091]. Furthermore it is known that viral infections, as lytic HSV-1 infection induce EGR-1 expression in infected cells and that this seems to enhance viral replication [Bedadala et al., Virol J, 2011, 8:262; Hsia et al., Br Microbiol Res J}, 2013, 3:706-723].
The gene overlaps with LOC100652898.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 17 | 33 | 31 | 13 | 21 | 411 | 16 | 63 | 36 |
Read_Max |  | R. aegyptiacus | Transcriptome | 189 | 203 | 154 | 147 | 141 | 349 | 118 | 196 | 337 |
Read_Max |  | R. aegyptiacus | Genome | 193 | 125 | 132 | 186 | 120 | 241 | 107 | 259 | 374 |
DESeq | | H. sapiens | Genome | 129.88 | 287.58 | 308.78 | 137.88 | 179.04 | 4111.94 | 148.37 | 444.64 | 326.12 |
DESeq | | R. aegyptiacus | Transcriptome | 1230.97 | 1995.19 | 1620.76 | 1135.51 | 1228.6 | 2577.63 | 1133.43 | 1237.83 | 2050.44 |
DESeq | | R. aegyptiacus | Genome | 1776.36 | 1600.85 | 2484.84 | 2966.4 | 2074.89 | 4905.73 | 1963.43 | 2029.15 | 3368.26 |