HMGCS2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HMGCS2 B7Z8R3, HMCS2_HUMAN, NM_005518, NP_005509, P54868, Q5SZU2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) NM_005518 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene belongs to the HMG-CoA synthase family. Itis a mitochondrial enzyme that catalyzes the first reaction of ketogenesis,a metabolic pathway that provides lipid-derived energy for various organsduring times of carbohydrate deprivation, such as fasting. Mutations in thisgene are associated with HMG-CoA synthase deficiency.

The gene is equally expressed in all human cells probes. We found no homolog inbat cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome11 17 10 18 13 3 14 16 3
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 131.91 104.01 93.33 144.73 96.12 6.26 101.88 101.72 22.75
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 131.91 144.73 101.88 0.13 -0.37 -0.51
7h 104.01 96.12 101.72 -0.11 -0.03 0.08
23h 93.33 6.26 22.75 -3.9 -2.04 1.86

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 131.91 104.01 93.33 -0.34 -0.5 -0.16
Ebov 144.73 96.12 6.26 -0.59 -4.53 -3.94
Marv 101.88 101.72 22.75 -0.0 -2.16 -2.16

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA