MAFK

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAFK P18, NFE2U v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K NM_002360 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase.

MAFK is very strongly and exclusively induced in the human EBOV infected cells 23 hours after infection. Beside, the alternative first exon in the human annotation, seems to be missing in the bat assembly data.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome29 23 21 31 29 572 38 42 50
Read_Max
batR. aegyptiacusTranscriptome 22 30 15 25 28 52 28 48 33
Read_Max
bat_genomeR. aegyptiacusGenome 27 30 13 30 24 30 25 50 42
DESeq
humanH. sapiensGenome 560.15 538.47 471.6 699.1 555.43 10275.72 718.55 759.58 1036.15
DESeq
batR. aegyptiacusTranscriptome 60.65 90.86 62.08 82.49 110.51 161.4 85.54 126.58 98.97
DESeq
bat_genomeR. aegyptiacusGenome 333.44 468.21 273.37 359.44 515.65 650.09 410.45 434.53 546.25

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 560.15 699.1 718.55 0.32 0.36 0.04
7h 538.47 555.43 759.58 0.04 0.5 0.45
23h 471.6 10275.72 1036.15 4.45 1.14 -3.31

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 560.15 538.47 471.6 -0.06 -0.25 -0.19
Ebov 699.1 555.43 10275.72 -0.33 3.88 4.21
Marv 718.55 759.58 1036.15 0.08 0.53 0.45

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 60.65 82.49 85.54 0.44 0.5 0.05
7h 90.86 110.51 126.58 0.28 0.48 0.2
23h 62.08 161.4 98.97 1.38 0.67 -0.71

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 60.65 90.86 62.08 0.58 0.03 -0.55
Ebov 82.49 110.51 161.4 0.42 0.97 0.55
Marv 85.54 126.58 98.97 0.57 0.21 -0.35