Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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SQSTM1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
SQSTM1	A170, OSIL, PDB3, ZIP3, p60, p62, p62B,p62, A170	sequestosome 1		pdf

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Description

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

\gene{SQSTM1/\update (Sequestosome 1) encodes a multifunctional protein that can bind ubiquitin and regulates activation of NF$\kappa$B signaling pathway [Duran \emph, Cancer Cell, 2008, 13:343-354]. It was shown that two degradation systems, the ubiquitin-proteasome system and autophagy, share certain regulatory molecules. Ubiquitin-binding autophagic adaptor SQSTM1/\update is one of those. It binds polyubiquitinylated proteins and targets them to proteasomal degradation as well as it may selectively recognize autophagic cargo and mediate uptake into autophagosomes. NUP62 protein has six main domains necessary for its interactions with different signaling pathways [Lippai and L\"ow, Biomed Res Int, 2014, 2014:832704; Seibenhener et al., FEBS Lett, 2007, 581:175-179]. For HIV it was shown that interaction of viral protein Tat with NUP62/\update leads to degradation of Tat protein, but this event is rapidly counteracted by the virus to retain viral replication [Sagnier et al., J Virol, 2015, 89:615-625].

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