SQSTM1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SQSTM1 A170, OSIL, PDB3, ZIP3, p60, p62, p62B,p62, A170 sequestosome 1 pdf

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Description

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

\gene{SQSTM1/\update (Sequestosome 1) encodes a multifunctional protein that can bind ubiquitin and regulates activation of NF$\kappa$B signaling pathway [Duran \emph, Cancer Cell, 2008, 13:343-354]. It was shown that two degradation systems, the ubiquitin-proteasome system and autophagy, share certain regulatory molecules. Ubiquitin-binding autophagic adaptor SQSTM1/\update is one of those. It binds polyubiquitinylated proteins and targets them to proteasomal degradation as well as it may selectively recognize autophagic cargo and mediate uptake into autophagosomes. NUP62 protein has six main domains necessary for its interactions with different signaling pathways [Lippai and L\"ow, Biomed Res Int, 2014, 2014:832704; Seibenhener et al., FEBS Lett, 2007, 581:175-179]. For HIV it was shown that interaction of viral protein Tat with NUP62/\update leads to degradation of Tat protein, but this event is rapidly counteracted by the virus to retain viral replication [Sagnier et al., J Virol, 2015, 89:615-625].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome626 796 788 704 1383 6018 974 1606 1939
Read_Max
batR. aegyptiacusTranscriptome 103 114 209 100 80 752 61 104 344
Read_Max
bat_genomeR. aegyptiacusGenome 125 101 168 99 64 404 63 139 349
DESeq
humanH. sapiensGenome 8546.52 10111.0 8899.69 10081.22 11349.79 57604.18 10821.32 16030.37 22593.89
DESeq
batR. aegyptiacusTranscriptome 715.96 768.91 1771.01 725.29 717.19 5436.56 566.1 738.8 2164.15
DESeq
bat_genomeR. aegyptiacusGenome 1090.57 1072.4 2545.09 1041.8 1108.32 8533.46 890.63 1026.87 3266.37

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8546.52 10081.22 10821.32 0.24 0.34 0.1
7h 10111.0 11349.79 16030.37 0.17 0.66 0.5
23h 8899.69 57604.18 22593.89 2.69 1.34 -1.35

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8546.52 10111.0 8899.69 0.24 0.06 -0.18
Ebov 10081.22 11349.79 57604.18 0.17 2.51 2.34
Marv 10821.32 16030.37 22593.89 0.57 1.06 0.5

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 715.96 725.29 566.1 0.02 -0.34 -0.36
7h 768.91 717.19 738.8 -0.1 -0.06 0.04
23h 1771.01 5436.56 2164.15 1.62 0.29 -1.33

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 715.96 768.91 1771.01 0.1 1.31 1.2
Ebov 725.29 717.19 5436.56 -0.02 2.91 2.92
Marv 566.1 738.8 2164.15 0.38 1.93 1.55