SLC9A1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
SLC9A1	AK124218, NM_003047, NP_003038, Q5TBB3, Q5TBB3_HUMAN, RP4-633N17.1-003,PPP1R143	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	NM_003047	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 (SLC9A1), transcript variant 2 gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth.

In HG19 MOCK this gene is downregulated, but upregulated during ebola infection, while marburg infection doesn't affect the expression level. In the RAE samples the amount of transcripts increase for ebola and marburg infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	30	27	14	24	32	76	29	29	29
Read_Max	R. aegyptiacus	Transcriptome	60	56	34	41	31	62	39	49	57
Read_Max	R. aegyptiacus	Genome	66	45	29	51	28	35	28	59	56
DESeq	H. sapiens	Genome	636.26	479.32	348.49	564.5	407.48	1626.16	507.15	487.8	419.63
DESeq	R. aegyptiacus	Transcriptome	702.52	670.88	591.0	499.12	491.6	819.67	551.64	435.59	568.69
DESeq	R. aegyptiacus	Genome	1193.69	894.43	1009.78	1223.49	856.07	1433.34	965.97	812.77	1066.81

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	636.26	564.5	507.15	-0.17	-0.33	-0.15
7h	479.32	407.48	487.8	-0.23	0.03	0.26
23h	348.49	1626.16	419.63	2.22	0.27	-1.95

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	636.26	479.32	348.49	-0.41	-0.87	-0.46
Ebov	564.5	407.48	1626.16	-0.47	1.53	2.0
Marv	507.15	487.8	419.63	-0.06	-0.27	-0.22

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	702.52	499.12	551.64	-0.49	-0.35	0.14
7h	670.88	491.6	435.59	-0.45	-0.62	-0.17
23h	591.0	819.67	568.69	0.47	-0.06	-0.53

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	702.52	670.88	591.0	-0.07	-0.25	-0.18
Ebov	499.12	491.6	819.67	-0.02	0.72	0.74
Marv	551.64	435.59	568.69	-0.34	0.04	0.38

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material