RELN

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
RELN	LIS2, PRO1598, RL,RL	reelin	NM_005045	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia.

This gene is upregulated in Ebola infected cells in human cells. No homolog in bat cells was found.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	152	195	254	151	396	816	158	198	238
Read_Max	R. aegyptiacus	Transcriptome	1	NA	NA	2	NA	1	2	1	NA
Read_Max	R. aegyptiacus	Genome	2	2	2	3	2	2	2	3	2
DESeq	H. sapiens	Genome	7858.49	9827.48	10010.66	7237.49	10071.83	32406.9	6906.36	7945.74	8900.93
DESeq	R. aegyptiacus	Transcriptome	1.84	1.0	1.0	2.83	1.0	2.28	3.22	2.65	1.0
DESeq	R. aegyptiacus	Genome	11.17	24.64	16.74	7.9	15.63	18.28	13.49	11.1	10.27

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7858.49	7237.49	6906.36	-0.12	-0.19	-0.07
7h	9827.48	10071.83	7945.74	0.04	-0.31	-0.34
23h	10010.66	32406.9	8900.93	1.69	-0.17	-1.86

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7858.49	9827.48	10010.66	0.32	0.35	0.03
Ebov	7237.49	10071.83	32406.9	0.48	2.16	1.69
Marv	6906.36	7945.74	8900.93	0.2	0.37	0.16

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1.84	2.83	3.22	0.62	0.81	0.19
7h	1.0	1.0	2.65	0.0	1.41	1.41
23h	1.0	2.28	1.0	1.19	0.0	-1.19

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1.84	1.0	1.0	-0.88	-0.88	0.0
Ebov	2.83	1.0	2.28	-1.5	-0.31	1.19
Marv	3.22	2.65	1.0	-0.28	-1.69	-1.41

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material