TRIM8

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TRIM8	A6NI31, GERP, NM_030912, NP_112174, Q9BZR9, Q9C028, RNF27, TRIM8_HUMAN,GERP	tripartite motif containing 8	NM_030912	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes.

While this gene does not show any differential expression for MOCK and MARV samples, there is a strong upregulation for EBOV-infected cells between 7 h and 23 h p.i.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	108	110	113	121	118	414	127	139	120
Read_Max	R. aegyptiacus	Transcriptome	437	327	305	346	296	648	401	455	523
Read_Max	R. aegyptiacus	Genome	461	337	263	313	250	390	341	544	635
DESeq	H. sapiens	Genome	1385.17	1182.01	1352.23	1482.75	1109.05	4817.28	1265.05	1287.95	1472.18
DESeq	R. aegyptiacus	Transcriptome	3870.69	3222.39	3522.69	3204.01	3232.61	6038.37	4065.73	3476.03	3917.07
DESeq	R. aegyptiacus	Genome	6095.65	5142.07	5563.27	5405.49	5350.75	9725.3	6675.22	5407.89	6261.33

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1385.17	1482.75	1265.05	0.1	-0.13	-0.23
7h	1182.01	1109.05	1287.95	-0.09	0.12	0.22
23h	1352.23	4817.28	1472.18	1.83	0.12	-1.71

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1385.17	1182.01	1352.23	-0.23	-0.03	0.19
Ebov	1482.75	1109.05	4817.28	-0.42	1.7	2.12
Marv	1265.05	1287.95	1472.18	0.03	0.22	0.19

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3870.69	3204.01	4065.73	-0.27	0.07	0.34
7h	3222.39	3232.61	3476.03	0.0	0.11	0.1
23h	3522.69	6038.37	3917.07	0.78	0.15	-0.62

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3870.69	3222.39	3522.69	-0.26	-0.14	0.13
Ebov	3204.01	3232.61	6038.37	0.01	0.91	0.9
Marv	4065.73	3476.03	3917.07	-0.23	-0.05	0.17

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material