CPSF6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CPSF6 CFIM, HPBRII-4, HPBRII-7, CFIM68 cleavage and polyadenylation specific factor 6, 68kDa NM_007007 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.

The gene seems to be down regulated 23 h after infection with Ebola or Marburg respectively.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome502 533 497 478 664 219 632 840 341
Read_Max
batR. aegyptiacusTranscriptome 543 427 276 451 335 288 337 459 343
Read_Max
bat_genomeR. aegyptiacusGenome 789 597 300 529 368 203 343 718 468
DESeq
humanH. sapiensGenome 7140.03 6677.09 7912.82 6388.83 7181.79 2205.17 6473.02 6800.27 6335.88
DESeq
batR. aegyptiacusTranscriptome 3156.57 2751.3 2324.36 2778.22 2620.46 1788.47 2852.1 2630.0 1922.74
DESeq
bat_genomeR. aegyptiacusGenome 7762.01 6870.69 5278.74 6585.53 6353.03 4424.03 6952.98 6481.54 4864.02

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7140.03 6388.83 6473.02 -0.16 -0.14 0.02
7h 6677.09 7181.79 6800.27 0.11 0.03 -0.08
23h 7912.82 2205.17 6335.88 -1.84 -0.32 1.52

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7140.03 6677.09 7912.82 -0.1 0.15 0.24
Ebov 6388.83 7181.79 2205.17 0.17 -1.53 -1.7
Marv 6473.02 6800.27 6335.88 0.07 -0.03 -0.1

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3156.57 2778.22 2852.1 -0.18 -0.15 0.04
7h 2751.3 2620.46 2630.0 -0.07 -0.07 0.01
23h 2324.36 1788.47 1922.74 -0.38 -0.27 0.1

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3156.57 2751.3 2324.36 -0.2 -0.44 -0.24
Ebov 2778.22 2620.46 1788.47 -0.08 -0.64 -0.55
Marv 2852.1 2630.0 1922.74 -0.12 -0.57 -0.45