TMED7-TICAM2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TMED7-TICAM2 ENSG00000251201, ENSG00000243414 TMED7-TICAM2 readthrough NM_001164468 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway.

This gene is upregulated in Ebola infected cells after 7 h and 23 h.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome724 559 673 502 779 197 678 626 580
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 8539.42 6615.9 8344.7 6224.57 7517.54 2460.46 6140.56 5567.68 8027.79
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8539.42 6224.57 6140.56 -0.46 -0.48 -0.02
7h 6615.9 7517.54 5567.68 0.18 -0.25 -0.43
23h 8344.7 2460.46 8027.79 -1.76 -0.06 1.71

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8539.42 6615.9 8344.7 -0.37 -0.03 0.33
Ebov 6224.57 7517.54 2460.46 0.27 -1.34 -1.61
Marv 6140.56 5567.68 8027.79 -0.14 0.39 0.53

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA