CLDN3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CLDN3 Claudin,SEMP1,ILVASC,CLD1,RVP1, CPE-R2, HRVP1 claudin 3 NM_001306 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.

Some differences but low expression level.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome2 3 2 2 6 2 4 3 1
Read_Max
batR. aegyptiacusTranscriptome 28 39 76 59 63 46 22 70 85
Read_Max
bat_genomeR. aegyptiacusGenome 0 0 2 0 2 1 0 1 2
DESeq
humanH. sapiensGenome 5.06 13.24 4.97 5.56 15.63 2.32 13.28 9.79 2.09
DESeq
batR. aegyptiacusTranscriptome 92.58 107.2 269.74 224.42 235.35 165.25 59.96 189.38 285.28
DESeq
bat_genomeR. aegyptiacusGenome 0.0 0.0 2.23 0.0 2.23 1.31 0.0 1.59 5.14

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5.06 5.56 13.28 0.14 1.39 1.26
7h 13.24 15.63 9.79 0.24 -0.44 -0.67
23h 4.97 2.32 2.09 -1.1 -1.25 -0.15

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5.06 13.24 4.97 1.39 -0.03 -1.41
Ebov 5.56 15.63 2.32 1.49 -1.26 -2.75
Marv 13.28 9.79 2.09 -0.44 -2.67 -2.23

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 92.58 224.42 59.96 1.28 -0.63 -1.9
7h 107.2 235.35 189.38 1.13 0.82 -0.31
23h 269.74 165.25 285.28 -0.71 0.08 0.79

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 92.58 107.2 269.74 0.21 1.54 1.33
Ebov 224.42 235.35 165.25 0.07 -0.44 -0.51
Marv 59.96 189.38 285.28 1.66 2.25 0.59