IL1A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
IL1A Interleukin 1, Alpha     IL-1 Alpha IL11    IL-1A2hematopoietin-11     IL1-ALPHA2Preinterleukin 1 Alpha1     Interleukin-1 Alpha pro-interleukin-1-alpha ,IL1F1, IL-1A, IL1-ALPHA interleukin 1, alpha NM_000575 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.

The gene IL1A is very low expressed in all analyzed datasets, and shows awkward read profiles.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome2 2 4 0 0 3 2 1 2
Read_Max
batR. aegyptiacusTranscriptome NA NA 2 NA NA NA NA 3 NA
Read_Max
bat_genomeR. aegyptiacusGenome 21 31 13 19 18 9 22 28 21
DESeq
humanH. sapiensGenome 9.12 7.12 1.99 1.0 1.0 3.63 4.51 2.6 10.79
DESeq
batR. aegyptiacusTranscriptome 1.0 1.0 3.44 1.0 1.0 1.0 1.0 5.13 1.0
DESeq
bat_genomeR. aegyptiacusGenome 28.36 35.59 37.94 15.8 47.99 6.53 30.36 55.51 29.11

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 9.12 1.0 4.51 -3.19 -1.02 2.17
7h 7.12 1.0 2.6 -2.83 -1.45 1.38
23h 1.99 3.63 10.79 0.87 2.44 1.57

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 9.12 7.12 1.99 -0.36 -2.2 -1.84
Ebov 1.0 1.0 3.63 0.0 1.86 1.86
Marv 4.51 2.6 10.79 -0.79 1.26 2.05

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 1.0 0.0 0.0 0.0
7h 1.0 1.0 5.13 0.0 2.36 2.36
23h 3.44 1.0 1.0 -1.78 -1.78 0.0

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 3.44 0.0 1.78 1.78
Ebov 1.0 1.0 1.0 0.0 0.0 0.0
Marv 1.0 5.13 1.0 2.36 0.0 -2.36