NFKB1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NFKB1 DNA-Binding Factor KBF1, NF-kappa-B, DNA Binding Factor KBF1, p50, p105,KBF1, NFKB-p50, NF-kappaB, NFkappaB, NF-kB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 NM_003998 pdf

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Description

The gene NFKFB1 encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.

No changes of expressions rates and patterns between datasets.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome197 208 236 198 280 804 242 276 178
Read_Max
batR. aegyptiacusTranscriptome 154 105 108 110 105 209 107 146 121
Read_Max
bat_genomeR. aegyptiacusGenome 172 116 108 150 93 144 92 174 154
DESeq
humanH. sapiensGenome 3211.79 3613.39 3481.84 3570.2 3614.57 12586.48 3287.01 3736.36 3017.3
DESeq
batR. aegyptiacusTranscriptome 1498.97 1473.27 1568.23 1285.68 1251.59 2908.69 1332.55 1219.66 1392.66
DESeq
bat_genomeR. aegyptiacusGenome 1874.33 1627.32 2107.7 1854.49 1658.57 3535.05 1776.76 1564.48 1862.22

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3211.79 3570.2 3287.01 0.15 0.03 -0.12
7h 3613.39 3614.57 3736.36 0.0 0.05 0.05
23h 3481.84 12586.48 3017.3 1.85 -0.21 -2.06

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3211.79 3613.39 3481.84 0.17 0.12 -0.05
Ebov 3570.2 3614.57 12586.48 0.02 1.82 1.8
Marv 3287.01 3736.36 3017.3 0.18 -0.12 -0.31

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1498.97 1285.68 1332.55 -0.22 -0.17 0.05
7h 1473.27 1251.59 1219.66 -0.24 -0.27 -0.04
23h 1568.23 2908.69 1392.66 0.89 -0.17 -1.06

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1498.97 1473.27 1568.23 -0.02 0.07 0.09
Ebov 1285.68 1251.59 2908.69 -0.04 1.18 1.22
Marv 1332.55 1219.66 1392.66 -0.13 0.06 0.19