Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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NFKB1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
NFKB1	DNA-Binding Factor KBF1, NF-kappa-B, DNA Binding Factor KBF1, p50, p105,KBF1, NFKB-p50, NF-kappaB, NFkappaB, NF-kB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	NM_003998	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The gene NFKFB1 encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.

No changes of expressions rates and patterns between datasets.

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