BCL2A1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
BCL2A1 GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5,GRS, BFL1, BCL2L5, ACC-1, ACC-2, ACC2, ACC1 BCL2-related protein A1 NM_004049 pdf NONE NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

This gene was found to be not expressed in all of our human cells probes but a very low expression level in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome0 0 0 2 0 3 2 0 1
Read_Max
batR. aegyptiacusTranscriptome 22 24 10 21 22 21 24 30 22
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 1.0 1.0 1.0 3.28 1.0 7.58 2.75 1.0 1.0
DESeq
batR. aegyptiacusTranscriptome 57.29 78.15 53.53 61.43 66.71 69.01 87.77 77.84 62.23
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 3.28 2.75 1.71 1.46 -0.25
7h 1.0 1.0 1.0 0.0 0.0 0.0
23h 1.0 7.58 1.0 2.92 0.0 -2.92

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 1.0 0.0 0.0 0.0
Ebov 3.28 1.0 7.58 -1.71 1.21 2.92
Marv 2.75 1.0 1.0 -1.46 -1.46 0.0

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 57.29 61.43 87.77 0.1 0.62 0.51
7h 78.15 66.71 77.84 -0.23 -0.01 0.22
23h 53.53 69.01 62.23 0.37 0.22 -0.15

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 57.29 78.15 53.53 0.45 -0.1 -0.55
Ebov 61.43 66.71 69.01 0.12 0.17 0.05
Marv 87.77 77.84 62.23 -0.17 -0.5 -0.32