BCL2A1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
BCL2A1	GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5,GRS, BFL1, BCL2L5, ACC-1, ACC-2, ACC2, ACC1	BCL2-related protein A1	NM_004049	pdf		NONE		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

This gene was found to be not expressed in all of our human cells probes but a very low expression level in bat cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	0	0	0	2	0	3	2	0	1
Read_Max	R. aegyptiacus	Transcriptome	22	24	10	21	22	21	24	30	22
Read_Max	R. aegyptiacus	Genome	NA	NA	NA	NA	NA	NA	NA	NA	NA
DESeq	H. sapiens	Genome	1.0	1.0	1.0	3.28	1.0	7.58	2.75	1.0	1.0
DESeq	R. aegyptiacus	Transcriptome	57.29	78.15	53.53	61.43	66.71	69.01	87.77	77.84	62.23
DESeq	R. aegyptiacus	Genome	NA	NA	NA	NA	NA	NA	NA	NA	NA

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1.0	3.28	2.75	1.71	1.46	-0.25
7h	1.0	1.0	1.0	0.0	0.0	0.0
23h	1.0	7.58	1.0	2.92	0.0	-2.92

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1.0	1.0	1.0	0.0	0.0	0.0
Ebov	3.28	1.0	7.58	-1.71	1.21	2.92
Marv	2.75	1.0	1.0	-1.46	-1.46	0.0

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	57.29	61.43	87.77	0.1	0.62	0.51
7h	78.15	66.71	77.84	-0.23	-0.01	0.22
23h	53.53	69.01	62.23	0.37	0.22	-0.15

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	57.29	78.15	53.53	0.45	-0.1	-0.55
Ebov	61.43	66.71	69.01	0.12	0.17	0.05
Marv	87.77	77.84	62.23	-0.17	-0.5	-0.32

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material