TGFB2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TGFB2 TGFB2, LDS4, TGF-beta2 transforming growth factor, beta 2 NM_003238 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth.

No modulation of gene expression for TGFB2 was observed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome11 11 14 18 14 28 20 15 29
Read_Max
batR. aegyptiacusTranscriptome 2508 2255 1348 1901 1408 1398 1925 1953 1664
Read_Max
bat_genomeR. aegyptiacusGenome 3274 2421 1634 2400 1853 1439 2524 3495 2795
DESeq
humanH. sapiensGenome 148.14 128.48 172.76 183.51 153.83 485.26 215.04 194.44 514.23
DESeq
batR. aegyptiacusTranscriptome 13975.06 13827.84 10545.3 11518.28 10785.45 9660.79 14359.94 10559.94 9256.29
DESeq
bat_genomeR. aegyptiacusGenome 25379.51 20808.3 18835.44 25512.63 20781.3 17615.2 26833.58 19044.18 16640.09

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 148.14 183.51 215.04 0.31 0.54 0.23
7h 128.48 153.83 194.44 0.26 0.6 0.34
23h 172.76 485.26 514.23 1.49 1.57 0.08

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 148.14 128.48 172.76 -0.21 0.22 0.43
Ebov 183.51 153.83 485.26 -0.25 1.4 1.66
Marv 215.04 194.44 514.23 -0.15 1.26 1.4

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 13975.06 11518.28 14359.94 -0.28 0.04 0.32
7h 13827.84 10785.45 10559.94 -0.36 -0.39 -0.03
23h 10545.3 9660.79 9256.29 -0.13 -0.19 -0.06

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 13975.06 13827.84 10545.3 -0.02 -0.41 -0.39
Ebov 11518.28 10785.45 9660.79 -0.09 -0.25 -0.16
Marv 14359.94 10559.94 9256.29 -0.44 -0.63 -0.19