MAPK8IP3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MAPK8IP3	MAPK8IP3, JIP3, JSAP1, SYD2, syd,KIAA1066	mitogen-activated protein kinase 8 interacting protein 3	NM_001040439	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells.

Although the expression pattern is unremarkable in Ebola and Marburg virus infection, interestingly, the putative bat cells homologous gene shows a pronounced possible editing at its 3'~end

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	40	49	50	35	59	109	47	82	46
Read_Max	R. aegyptiacus	Transcriptome	8	13	9	12	6	10	6	14	14
Read_Max	R. aegyptiacus	Genome	27	30	24	28	19	15	14	40	42
DESeq	H. sapiens	Genome	1142.64	1517.55	1576.61	1413.17	1474.07	3518.46	1488.74	1865.09	1396.07
DESeq	R. aegyptiacus	Transcriptome	111.9	127.17	175.68	131.94	89.7	99.8	85.54	113.36	146.2
DESeq	R. aegyptiacus	Genome	602.43	678.12	910.47	597.43	591.55	520.86	454.31	719.2	611.32

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1142.64	1413.17	1488.74	0.31	0.38	0.08
7h	1517.55	1474.07	1865.09	-0.04	0.3	0.34
23h	1576.61	3518.46	1396.07	1.16	-0.18	-1.33

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1142.64	1517.55	1576.61	0.41	0.46	0.06
Ebov	1413.17	1474.07	3518.46	0.06	1.32	1.26
Marv	1488.74	1865.09	1396.07	0.33	-0.09	-0.42

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	111.9	131.94	85.54	0.24	-0.39	-0.63
7h	127.17	89.7	113.36	-0.5	-0.17	0.34
23h	175.68	99.8	146.2	-0.82	-0.27	0.55

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	111.9	127.17	175.68	0.18	0.65	0.47
Ebov	131.94	89.7	99.8	-0.56	-0.4	0.15
Marv	85.54	113.36	146.2	0.41	0.77	0.37

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material