IKBKE

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
IKBKE	IKK-E, KIAA0151,IKKE, IKK-i	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that isessential for regulating antiviral signaling pathways. IKBKE has also beenidentified as a breast cancer (MIM 114480) oncogene and is amplified andoverexpressed in over 30\,\% of breast carcinomas and breast cancer celllines~\citehutti2009.

The gene IKBKE is weakly expressed throughout human cells and bat cells datasets.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	14	20	22	24	29	73	27	28	30
Read_Max	R. aegyptiacus	Transcriptome	21	18	43	18	16	36	17	19	53
Read_Max	R. aegyptiacus	Genome	37	41	62	26	23	36	31	40	137
DESeq	H. sapiens	Genome	214.11	212.11	253.18	255.37	250.58	856.35	271.18	275.98	383.75
DESeq	R. aegyptiacus	Transcriptome	218.6	193.43	496.94	192.37	181.69	453.96	182.32	178.63	554.69
DESeq	R. aegyptiacus	Genome	566.34	542.13	1568.78	523.37	582.62	1306.72	509.41	526.52	1614.78

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	214.11	255.37	271.18	0.25	0.34	0.09
7h	212.11	250.58	275.98	0.24	0.38	0.14
23h	253.18	856.35	383.75	1.76	0.6	-1.16

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	214.11	212.11	253.18	-0.01	0.24	0.26
Ebov	255.37	250.58	856.35	-0.03	1.75	1.77
Marv	271.18	275.98	383.75	0.03	0.5	0.48

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	218.6	192.37	182.32	-0.18	-0.26	-0.08
7h	193.43	181.69	178.63	-0.09	-0.11	-0.02
23h	496.94	453.96	554.69	-0.13	0.16	0.29

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	218.6	193.43	496.94	-0.18	1.18	1.36
Ebov	192.37	181.69	453.96	-0.08	1.24	1.32
Marv	182.32	178.63	554.69	-0.03	1.61	1.63

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material