IKBKE

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
IKBKE IKK-E, KIAA0151,IKKE, IKK-i inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon pdf

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Description

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that isessential for regulating antiviral signaling pathways. IKBKE has also beenidentified as a breast cancer (MIM 114480) oncogene and is amplified andoverexpressed in over 30\,\% of breast carcinomas and breast cancer celllines~\citehutti2009.

The gene IKBKE is weakly expressed throughout human cells and bat cells datasets.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome14 20 22 24 29 73 27 28 30
Read_Max
batR. aegyptiacusTranscriptome 21 18 43 18 16 36 17 19 53
Read_Max
bat_genomeR. aegyptiacusGenome 37 41 62 26 23 36 31 40 137
DESeq
humanH. sapiensGenome 214.11 212.11 253.18 255.37 250.58 856.35 271.18 275.98 383.75
DESeq
batR. aegyptiacusTranscriptome 218.6 193.43 496.94 192.37 181.69 453.96 182.32 178.63 554.69
DESeq
bat_genomeR. aegyptiacusGenome 566.34 542.13 1568.78 523.37 582.62 1306.72 509.41 526.52 1614.78

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 214.11 255.37 271.18 0.25 0.34 0.09
7h 212.11 250.58 275.98 0.24 0.38 0.14
23h 253.18 856.35 383.75 1.76 0.6 -1.16

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 214.11 212.11 253.18 -0.01 0.24 0.26
Ebov 255.37 250.58 856.35 -0.03 1.75 1.77
Marv 271.18 275.98 383.75 0.03 0.5 0.48

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 218.6 192.37 182.32 -0.18 -0.26 -0.08
7h 193.43 181.69 178.63 -0.09 -0.11 -0.02
23h 496.94 453.96 554.69 -0.13 0.16 0.29

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 218.6 193.43 496.94 -0.18 1.18 1.36
Ebov 192.37 181.69 453.96 -0.08 1.24 1.32
Marv 182.32 178.63 554.69 -0.03 1.61 1.63