RPS6KA3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
RPS6KA3	CLS, HU-3, MRX19, RSK, RSK2,RSK	ribosomal protein S6 kinase, 90kDa, polypeptide 3	NM_004586	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

High expression in human but distinct downregulation after 23 h of Ebola virus and Marburg virus infection whereas expression in bat cells is constant. Additionally, many alternative splicing can be observed in the different human cells probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	3188	3583	4102	3106	4724	2143	4012	4070	1707
Read_Max	R. aegyptiacus	Transcriptome	252	155	104	176	164	211	162	218	162
Read_Max	R. aegyptiacus	Genome	265	181	84	142	131	107	147	242	158
DESeq	H. sapiens	Genome	84445.47	79159.46	87491.69	74835.52	85695.76	42911.91	72947.6	67864.26	42063.93
DESeq	R. aegyptiacus	Transcriptome	2465.13	1870.84	1403.32	2258.12	2078.39	2201.66	2447.18	2029.34	1654.2
DESeq	R. aegyptiacus	Genome	3315.53	2911.46	1801.98	2601.03	2882.97	3112.1	3326.37	2634.17	2203.84

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	84445.47	74835.52	72947.6	-0.17	-0.21	-0.04
7h	79159.46	85695.76	67864.26	0.11	-0.22	-0.34
23h	87491.69	42911.91	42063.93	-1.03	-1.06	-0.03

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	84445.47	79159.46	87491.69	-0.09	0.05	0.14
Ebov	74835.52	85695.76	42911.91	0.2	-0.8	-1.0
Marv	72947.6	67864.26	42063.93	-0.1	-0.79	-0.69

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2465.13	2258.12	2447.18	-0.13	-0.01	0.12
7h	1870.84	2078.39	2029.34	0.15	0.12	-0.03
23h	1403.32	2201.66	1654.2	0.65	0.24	-0.41

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2465.13	1870.84	1403.32	-0.4	-0.81	-0.41
Ebov	2258.12	2078.39	2201.66	-0.12	-0.04	0.08
Marv	2447.18	2029.34	1654.2	-0.27	-0.56	-0.29

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material