RHOA

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
RHOA	ARH12, ARHA, RHO12, RHOH12,RhoA, Rho12	ras homolog family member A	NM_001664	pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion.

The gene expression level decreases after 7 h and is stable after 23 h in both control samples. After infection the gene expression levels change. Based on Ebola infection the expression level increases after 7 h and decreases after 23 h in human cells, in bat cells the expression level decreases after 7 h and increases after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	2825	2024	1921	1983	2854	2549	2664	2659	2269
Read_Max	R. aegyptiacus	Transcriptome	1804	1678	1385	1446	1408	1667	1287	2109	2314
Read_Max	R. aegyptiacus	Genome	2728	1774	1257	2176	1304	1069	1286	2647	2622
DESeq	H. sapiens	Genome	19932.43	14480.14	12486.76	15869.04	14808.08	14813.02	15979.29	14564.37	16385.14
DESeq	R. aegyptiacus	Transcriptome	8133.56	8380.79	7939.77	7102.92	7625.02	8061.95	7201.6	8350.66	8941.4
DESeq	R. aegyptiacus	Genome	14576.11	12125.02	11695.58	15565.7	12829.96	13417.0	12559.9	13078.85	13793.25

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	19932.43	15869.04	15979.29	-0.33	-0.32	0.01
7h	14480.14	14808.08	14564.37	0.03	0.01	-0.02
23h	12486.76	14813.02	16385.14	0.25	0.39	0.15

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	19932.43	14480.14	12486.76	-0.46	-0.67	-0.21
Ebov	15869.04	14808.08	14813.02	-0.1	-0.1	0.0
Marv	15979.29	14564.37	16385.14	-0.13	0.04	0.17

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8133.56	7102.92	7201.6	-0.2	-0.18	0.02
7h	8380.79	7625.02	8350.66	-0.14	-0.01	0.13
23h	7939.77	8061.95	8941.4	0.02	0.17	0.15

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8133.56	8380.79	7939.77	0.04	-0.03	-0.08
Ebov	7102.92	7625.02	8061.95	0.1	0.18	0.08
Marv	7201.6	8350.66	8941.4	0.21	0.31	0.1

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material