PDCD6IP

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PDCD6IP Programmed Cell Death 6 Interacting Protein, DRIP4, AIP1, HP95,Alix, Hp95 programmed cell death 6 interacting protein pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

This gene is expressed in all samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome498 396 440 356 513 546 513 532 410
Read_Max
batR. aegyptiacusTranscriptome 691 590 379 601 484 538 501 656 546
Read_Max
bat_genomeR. aegyptiacusGenome 759 641 323 540 422 309 450 792 633
DESeq
humanH. sapiensGenome 7596.68 6703.6 7002.4 6752.7 6517.61 7978.12 6612.49 6315.87 6983.94
DESeq
batR. aegyptiacusTranscriptome 8047.87 7315.16 6459.26 7896.81 7671.01 7700.09 7614.31 7873.11 7092.26
DESeq
bat_genomeR. aegyptiacusGenome 9528.92 9399.74 7424.39 8876.49 9301.86 8991.66 9055.86 9367.07 8441.19

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7596.68 6752.7 6612.49 -0.17 -0.2 -0.03
7h 6703.6 6517.61 6315.87 -0.04 -0.09 -0.05
23h 7002.4 7978.12 6983.94 0.19 -0.0 -0.19

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7596.68 6703.6 7002.4 -0.18 -0.12 0.06
Ebov 6752.7 6517.61 7978.12 -0.05 0.24 0.29
Marv 6612.49 6315.87 6983.94 -0.07 0.08 0.15

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8047.87 7896.81 7614.31 -0.03 -0.08 -0.05
7h 7315.16 7671.01 7873.11 0.07 0.11 0.04
23h 6459.26 7700.09 7092.26 0.25 0.13 -0.12

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8047.87 7315.16 6459.26 -0.14 -0.32 -0.18
Ebov 7896.81 7671.01 7700.09 -0.04 -0.04 0.01
Marv 7614.31 7873.11 7092.26 0.05 -0.1 -0.15