GRK6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
GRK6 GPRK6 G protein-coupled receptor kinase 6 NM_002082 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation.

The gene is expressed in human cells and downregulated in Marburg infected cells after 23 h. The homolog is uniformly expressed in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome84 105 69 117 125 231 145 152 89
Read_Max
batR. aegyptiacusTranscriptome 104 130 84 111 90 120 92 127 117
Read_Max
bat_genomeR. aegyptiacusGenome 123 121 71 124 82 72 77 169 142
DESeq
humanH. sapiensGenome 949.83 1132.04 765.47 1072.1 974.1 2074.89 1143.12 1303.94 1118.79
DESeq
batR. aegyptiacusTranscriptome 921.79 1149.23 889.06 1009.15 983.3 1059.62 995.49 966.01 928.19
DESeq
bat_genomeR. aegyptiacusGenome 1352.68 1316.09 1167.1 1668.85 1321.5 1475.11 1394.42 1227.48 1266.31

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 949.83 1072.1 1143.12 0.17 0.27 0.09
7h 1132.04 974.1 1303.94 -0.22 0.2 0.42
23h 765.47 2074.89 1118.79 1.44 0.55 -0.89

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 949.83 1132.04 765.47 0.25 -0.31 -0.56
Ebov 1072.1 974.1 2074.89 -0.14 0.95 1.09
Marv 1143.12 1303.94 1118.79 0.19 -0.03 -0.22

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 921.79 1009.15 995.49 0.13 0.11 -0.02
7h 1149.23 983.3 966.01 -0.22 -0.25 -0.03
23h 889.06 1059.62 928.19 0.25 0.06 -0.19

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 921.79 1149.23 889.06 0.32 -0.05 -0.37
Ebov 1009.15 983.3 1059.62 -0.04 0.07 0.11
Marv 995.49 966.01 928.19 -0.04 -0.1 -0.06