PDK1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| PDK1 | pyruvate dehydrogenase kinase, isozyme 1 | NM_002610 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.
The gene is similarly expressed in all conditions. The homolog in bat cells seems not to have many splice variants.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 63 | 34 | 107 | 61 | 68 | 41 | 64 | 50 | 59 |
Read_Max |  | R. aegyptiacus | Transcriptome | 311 | 231 | 170 | 276 | 251 | 252 | 245 | 315 | 213 |
Read_Max |  | R. aegyptiacus | Genome | 363 | 304 | 151 | 231 | 222 | 149 | 217 | 395 | 248 |
DESeq | | H. sapiens | Genome | 802.68 | 546.63 | 1587.53 | 800.62 | 746.48 | 401.04 | 735.22 | 571.74 | 1217.74 |
DESeq | | R. aegyptiacus | Transcriptome | 1825.79 | 1635.75 | 1458.29 | 1592.43 | 1802.42 | 1525.42 | 1919.9 | 1681.51 | 1257.08 |
DESeq | | R. aegyptiacus | Genome | 5649.63 | 4740.49 | 3785.83 | 4849.53 | 5502.54 | 4860.04 | 6288.38 | 4931.33 | 3771.52 |