PDK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PDK1 pyruvate dehydrogenase kinase, isozyme 1 NM_002610 pdf

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Description

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.

The gene is similarly expressed in all conditions. The homolog in bat cells seems not to have many splice variants.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome63 34 107 61 68 41 64 50 59
Read_Max
batR. aegyptiacusTranscriptome 311 231 170 276 251 252 245 315 213
Read_Max
bat_genomeR. aegyptiacusGenome 363 304 151 231 222 149 217 395 248
DESeq
humanH. sapiensGenome 802.68 546.63 1587.53 800.62 746.48 401.04 735.22 571.74 1217.74
DESeq
batR. aegyptiacusTranscriptome 1825.79 1635.75 1458.29 1592.43 1802.42 1525.42 1919.9 1681.51 1257.08
DESeq
bat_genomeR. aegyptiacusGenome 5649.63 4740.49 3785.83 4849.53 5502.54 4860.04 6288.38 4931.33 3771.52

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 802.68 800.62 735.22 -0.0 -0.13 -0.12
7h 546.63 746.48 571.74 0.45 0.06 -0.38
23h 1587.53 401.04 1217.74 -1.98 -0.38 1.6

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 802.68 546.63 1587.53 -0.55 0.98 1.54
Ebov 800.62 746.48 401.04 -0.1 -1.0 -0.9
Marv 735.22 571.74 1217.74 -0.36 0.73 1.09

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1825.79 1592.43 1919.9 -0.2 0.07 0.27
7h 1635.75 1802.42 1681.51 0.14 0.04 -0.1
23h 1458.29 1525.42 1257.08 0.06 -0.21 -0.28

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1825.79 1635.75 1458.29 -0.16 -0.32 -0.17
Ebov 1592.43 1802.42 1525.42 0.18 -0.06 -0.24
Marv 1919.9 1681.51 1257.08 -0.19 -0.61 -0.42