MTOR

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MTOR	RAFT1, RAPT1, FLJ44809	mechanistic target of rapamycin (serine/threonine kinase)	NM_004958	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene belongs to a family of phosphatidylinositolkinase-related kinases. These kinases mediate cellular responses to stressessuch as DNA damage and nutrient deprivation. This protein acts as the targetfor the cell-cycle arrest and immunosuppressive effects of theFKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of thisgene.

The gene is slightly expressed in all conditions. The is some evidence foralternative splicing in the bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	202	263	243	196	355	383	271	335	166
Read_Max	R. aegyptiacus	Transcriptome	204	196	127	156	155	171	135	169	176
Read_Max	R. aegyptiacus	Genome	205	157	113	176	125	96	116	198	192
DESeq	H. sapiens	Genome	7854.44	8891.23	7677.52	8278.94	8426.42	10940.26	8133.57	8605.21	6498.98
DESeq	R. aegyptiacus	Transcriptome	6108.82	5917.32	4826.07	5569.18	5890.39	5945.98	5382.82	5125.15	5105.8
DESeq	R. aegyptiacus	Genome	6307.06	5708.84	4665.07	6470.98	6015.96	6202.0	5854.31	5075.65	5060.95

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7854.44	8278.94	8133.57	0.08	0.05	-0.03
7h	8891.23	8426.42	8605.21	-0.08	-0.05	0.03
23h	7677.52	10940.26	6498.98	0.51	-0.24	-0.75

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7854.44	8891.23	7677.52	0.18	-0.03	-0.21
Ebov	8278.94	8426.42	10940.26	0.03	0.4	0.38
Marv	8133.57	8605.21	6498.98	0.08	-0.32	-0.4

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	6108.82	5569.18	5382.82	-0.13	-0.18	-0.05
7h	5917.32	5890.39	5125.15	-0.01	-0.21	-0.2
23h	4826.07	5945.98	5105.8	0.3	0.08	-0.22

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	6108.82	5917.32	4826.07	-0.05	-0.34	-0.29
Ebov	5569.18	5890.39	5945.98	0.08	0.09	0.01
Marv	5382.82	5125.15	5105.8	-0.07	-0.08	-0.01

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material