CHMP1A
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| CHMP1A | CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A,KIAA0047, CHMP1, Vps46A | charged multivesicular body protein 1A | NM_002768 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene.
Expression in human is stable upon Ebola and Marburg infection, but apparently there are alternative isoforms involving exons 1 and 2. The bat cells homolog is expressed without variation.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 218 | 198 | 190 | 193 | 234 | 286 | 271 | 288 | 205 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 280 | 194 | 171 | 246 | 170 | 130 | 160 | 300 | 324 |
DESeq | | H. sapiens | Genome | 2602.91 | 2373.22 | 2185.21 | 2583.51 | 2208.97 | 2556.52 | 2718.58 | 2423.83 | 2409.47 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 1818.47 | 1703.98 | 1855.54 | 2048.04 | 1828.23 | 1818.44 | 2081.51 | 1750.03 | 1988.08 |