CHMP1A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CHMP1A CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A,KIAA0047, CHMP1, Vps46A charged multivesicular body protein 1A NM_002768 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene.

Expression in human is stable upon Ebola and Marburg infection, but apparently there are alternative isoforms involving exons 1 and 2. The bat cells homolog is expressed without variation.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome218 198 190 193 234 286 271 288 205
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 280 194 171 246 170 130 160 300 324
DESeq
humanH. sapiensGenome 2602.91 2373.22 2185.21 2583.51 2208.97 2556.52 2718.58 2423.83 2409.47
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 1818.47 1703.98 1855.54 2048.04 1828.23 1818.44 2081.51 1750.03 1988.08

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2602.91 2583.51 2718.58 -0.01 0.06 0.07
7h 2373.22 2208.97 2423.83 -0.1 0.03 0.13
23h 2185.21 2556.52 2409.47 0.23 0.14 -0.09

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2602.91 2373.22 2185.21 -0.13 -0.25 -0.12
Ebov 2583.51 2208.97 2556.52 -0.23 -0.02 0.21
Marv 2718.58 2423.83 2409.47 -0.17 -0.17 -0.01

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA