ADRBK1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| ADRBK1 | BARK1, BETA-ARK1, GRK2,GRK2, BARK1 | adrenergic, beta, receptor kinase 1 | NM_001619 |  |
NONE |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
The gene is upragulated upon Ebola infection in human cells, but shows no significant expression changes in bat cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 216 | 232 | 278 | 193 | 307 | 739 | 250 | 384 | 234 |
Read_Max |  | R. aegyptiacus | Transcriptome | 73 | 81 | 46 | 58 | 78 | 104 | 55 | 86 | 106 |
Read_Max |  | R. aegyptiacus | Genome | 74 | 65 | 39 | 79 | 66 | 51 | 57 | 95 | 111 |
DESeq | | H. sapiens | Genome | 3144.81 | 3830.62 | 3681.4 | 3287.31 | 3310.52 | 8587.39 | 3365.96 | 4339.87 | 3308.71 |
DESeq | | R. aegyptiacus | Transcriptome | 716.8 | 821.55 | 658.19 | 717.05 | 844.22 | 878.7 | 691.8 | 779.29 | 877.46 |
DESeq | | R. aegyptiacus | Genome | 861.97 | 919.07 | 807.82 | 1000.32 | 1097.16 | 994.72 | 878.26 | 899.2 | 1053.97 |