ADRBK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ADRBK1 BARK1, BETA-ARK1, GRK2,GRK2, BARK1 adrenergic, beta, receptor kinase 1 NM_001619 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

The gene is upragulated upon Ebola infection in human cells, but shows no significant expression changes in bat cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome216 232 278 193 307 739 250 384 234
Read_Max
batR. aegyptiacusTranscriptome 73 81 46 58 78 104 55 86 106
Read_Max
bat_genomeR. aegyptiacusGenome 74 65 39 79 66 51 57 95 111
DESeq
humanH. sapiensGenome 3144.81 3830.62 3681.4 3287.31 3310.52 8587.39 3365.96 4339.87 3308.71
DESeq
batR. aegyptiacusTranscriptome 716.8 821.55 658.19 717.05 844.22 878.7 691.8 779.29 877.46
DESeq
bat_genomeR. aegyptiacusGenome 861.97 919.07 807.82 1000.32 1097.16 994.72 878.26 899.2 1053.97

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3144.81 3287.31 3365.96 0.06 0.1 0.03
7h 3830.62 3310.52 4339.87 -0.21 0.18 0.39
23h 3681.4 8587.39 3308.71 1.22 -0.15 -1.38

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3144.81 3830.62 3681.4 0.28 0.23 -0.06
Ebov 3287.31 3310.52 8587.39 0.01 1.39 1.38
Marv 3365.96 4339.87 3308.71 0.37 -0.02 -0.39

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 716.8 717.05 691.8 0.0 -0.05 -0.05
7h 821.55 844.22 779.29 0.04 -0.08 -0.12
23h 658.19 878.7 877.46 0.42 0.41 -0.0

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 716.8 821.55 658.19 0.2 -0.12 -0.32
Ebov 717.05 844.22 878.7 0.24 0.29 0.06
Marv 691.8 779.29 877.46 0.17 0.34 0.17