VPS37A

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
VPS37A	HCRP1, PQBP2, SPG53,FLJ32642, HCRP1	vacuolar protein sorting 37 homolog A (S. cerevisiae)	NM_152415	pdf

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Description

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. Gene is upregulated in human EBOV 7h, but expression goes down again at 23h, and downregulated in bat EBOV7h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	170	154	110	146	243	190	144	186	106
Read_Max	R. aegyptiacus	Transcriptome	118	126	84	90	89	81	105	122	110
Read_Max	R. aegyptiacus	Genome	125	100	85	136	76	56	92	161	139
DESeq	H. sapiens	Genome	2075.22	1786.8	1938.99	1648.15	1935.01	1888.03	1762.43	1580.52	1798.38
DESeq	R. aegyptiacus	Transcriptome	642.03	594.63	582.45	588.86	566.07	525.82	729.63	566.95	566.94
DESeq	R. aegyptiacus	Genome	1008.92	954.67	834.6	1056.61	924.16	832.85	1099.79	952.33	901.57

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2075.22	1648.15	1762.43	-0.33	-0.24	0.1
7h	1786.8	1935.01	1580.52	0.11	-0.18	-0.29
23h	1938.99	1888.03	1798.38	-0.04	-0.11	-0.07

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2075.22	1786.8	1938.99	-0.22	-0.1	0.12
Ebov	1648.15	1935.01	1888.03	0.23	0.2	-0.04
Marv	1762.43	1580.52	1798.38	-0.16	0.03	0.19

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	642.03	588.86	729.63	-0.12	0.18	0.31
7h	594.63	566.07	566.95	-0.07	-0.07	0.0
23h	582.45	525.82	566.94	-0.15	-0.04	0.11

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	642.03	594.63	582.45	-0.11	-0.14	-0.03
Ebov	588.86	566.07	525.82	-0.06	-0.16	-0.11
Marv	729.63	566.95	566.94	-0.36	-0.36	0.0

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material