VPS37A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
VPS37A HCRP1, PQBP2, SPG53,FLJ32642, HCRP1 vacuolar protein sorting 37 homolog A (S. cerevisiae) NM_152415 pdf

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Description

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. Gene is upregulated in human EBOV 7h, but expression goes down again at 23h, and downregulated in bat EBOV7h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome170 154 110 146 243 190 144 186 106
Read_Max
batR. aegyptiacusTranscriptome 118 126 84 90 89 81 105 122 110
Read_Max
bat_genomeR. aegyptiacusGenome 125 100 85 136 76 56 92 161 139
DESeq
humanH. sapiensGenome 2075.22 1786.8 1938.99 1648.15 1935.01 1888.03 1762.43 1580.52 1798.38
DESeq
batR. aegyptiacusTranscriptome 642.03 594.63 582.45 588.86 566.07 525.82 729.63 566.95 566.94
DESeq
bat_genomeR. aegyptiacusGenome 1008.92 954.67 834.6 1056.61 924.16 832.85 1099.79 952.33 901.57

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2075.22 1648.15 1762.43 -0.33 -0.24 0.1
7h 1786.8 1935.01 1580.52 0.11 -0.18 -0.29
23h 1938.99 1888.03 1798.38 -0.04 -0.11 -0.07

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2075.22 1786.8 1938.99 -0.22 -0.1 0.12
Ebov 1648.15 1935.01 1888.03 0.23 0.2 -0.04
Marv 1762.43 1580.52 1798.38 -0.16 0.03 0.19

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 642.03 588.86 729.63 -0.12 0.18 0.31
7h 594.63 566.07 566.95 -0.07 -0.07 0.0
23h 582.45 525.82 566.94 -0.15 -0.04 0.11

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 642.03 594.63 582.45 -0.11 -0.14 -0.03
Ebov 588.86 566.07 525.82 -0.06 -0.16 -0.11
Marv 729.63 566.95 566.94 -0.36 -0.36 0.0